CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016555
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab11 family-interacting protein 4 
Protein Synonyms/Alias
 FIP4-Rab11; Rab11-FIP4; mRab11-FIP4A 
Gene Name
 Rab11fip4 
Gene Synonyms/Alias
 Kiaa1821 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
279YCSQCCKKINLLNDLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development, in a Rab11-independent manner. 
Sequence Annotation
 DOMAIN 49 84 EF-hand.
 DOMAIN 572 634 FIP-RBD.
 REGION 82 635 Necessary for interaction with RAB11A,  
Keyword
 Calcium; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasmic vesicle; Endosome; Membrane; Metal-binding; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 635 AA 
Protein Sequence
MAGGAGWAGA PAALLRSVRR LREVFEVCGR DPDGFLRVER VAALGLRFGQ GEEVEKLVKC 60
LDPNDLGRIN FKDFCRGVFA MKGCEELLKD VLSVESAGTL PCSPDIPDCV EQGSDFSGST 120
DGEQLPREPD FFQEDEEEAM TLALPEGPQE LDMDSPMESS QGPEGSVKGC GEEKEPELGG 180
LFLPEDKCLV LTPSVTTSDL STHSTASLIS NEEQFEDYGE GDDVDCAPSS PCPDDETRTN 240
VYSDLGSSVS SSAGQTPRKM RHAYNSELLD VYCSQCCKKI NLLNDLEARL KNLKANSPNR 300
KISSTAFGRQ LMHNSNFSSS NGSTEDLFRD SIDSCDNDIT EKVSFLEKKV TELENDSLTS 360
GGLKSKLKQE NMQLVHRVHE LEEMVKDQET TAEQALEEEA RRHREVYCKL EREKSTELEL 420
LNTRVQQLEE ENTDLRTTVA RLKSQTEKLD EERQRMSDRL EDTSLRLKDE MDLYKRMMDK 480
LRQNRLEFQK EREATQELIE DLRRELEHLQ MYKLDCERPG RGRSSSGLGE FNARAREVEL 540
EHEVKRLKQE NHKLRDQNDD LNGQILSLSL YEAKNLFATQ TKAQSLAAEI DTASRDELME 600
ALKEQEEINF RLRQYMDKII LAILDHNPSI LEIKH 635 
Gene Ontology
 GO:0032154; C:cleavage furrow; ISS:UniProtKB.
 GO:0030139; C:endocytic vesicle; ISS:UniProtKB.
 GO:0030496; C:midbody; ISS:UniProtKB.
 GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
 GO:0030306; F:ADP-ribosylation factor binding; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.
 GO:0000910; P:cytokinesis; ISS:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR019018; Rab-bd_FIP-RBD. 
Pfam
 PF09457; RBD-FIP 
SMART
  
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51511; FIP_RBD 
PRINTS