CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039115
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Eea1 
Protein Synonyms/Alias
  
Gene Name
 Eea1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
158NFNIKQMKDLFEQKAacetylation[1]
164MKDLFEQKAAQLATEacetylation[1]
310KSQTLMEKLQKKDLDacetylation[1]
324DYTHLEEKHNEEALSacetylation[1]
378GEAAQKLKEELREVEacetylation[1]
392ETKHQHLKVEFKQLQacetylation[1]
422EVSQLHSKLLETERQacetylation[1]
451SSEKLMDKEQQVADLacetylation[1]
461QVADLQLKLSRLEEQacetylation[1]
485ELQHQLEKSKQQHQEacetylation[1]
524QIGDKDQKIQNLEALacetylation[1]
534NLEALLQKSKENISLacetylation[1]
536EALLQKSKENISLLEacetylation[1]
583QLTQLMEKLKNQSESacetylation[1]
724KHLSLEQKAEDLEGQacetylation[1]
743EANNLEVKASREQAVacetylation[1]
785KEVVSHTKLDLQNKSacetylation[1]
791TKLDLQNKSEALENIacetylation[1]
813EEEKVVLKQEFEKLSacetylation[1]
898EKACKELKHQLQQQTacetylation[1]
910QQTESALKEQSELKKacetylation[1]
952NTLKQKEKEEQQLQGacetylation[1]
983EALQGELKNVTSQKAacetylation[1]
995QKAQLESKLQQQAAQacetylation[1]
1011AQELAVEKGKLSALQacetylation[1]
1093ALEQDLAKKEEVLKEacetylation[1]
1138EIKCRQEKEIAKLKEacetylation[1]
1142RQEKEIAKLKEELKSacetylation[1]
1148AKLKEELKSHKQESIacetylation[1]
1151KEELKSHKQESIKEVacetylation[1]
1162IKEVTNLKDAKQLLIacetylation[1]
1165VTNLKDAKQLLIQQKacetylation[1]
1172KQLLIQQKLELQGKVacetylation[1]
1178QKLELQGKVDSLKAAacetylation[1]
1183QGKVDSLKAALEQEKacetylation[1]
1190KAALEQEKERQQLMRacetylation[1]
1301ALLERCLKGEGEIEKacetylation[1]
1308KGEGEIEKLQTKVLEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1411 AA 
Protein Sequence
IFLSSLFQTP GRVGSQGSDL DSSATPINTV DVNNESSSEG FICPQCMKSL GSADELFKHY 60
QAVHDAGNDS GHGGEASLAL TRDDIALLRQ EVQDLQASLK EEKWYSEELK KELEKYQGLQ 120
QQEAKSDGLV TDSSAELQSL EQQLEEAQTE NFNIKQMKDL FEQKAAQLAT EIADIKSKYD 180
EEKGLRAAAE QKATHLTEEL SKQTTVIQDL KTELLQRPGI EDVAVLKKEL VQVQTLMDNM 240
TLERERESEK LKDECKKLQS EHANSEATIN QLRSELAKGP QEVAVYVQEI QKLKGSVNEL 300
TQKSQTLMEK LQKKDLDYTH LEEKHNEEAL SRKNTQAALH QRDLDCQQLQ ARLTASEGSL 360
QRIQGELREK GEAAQKLKEE LREVETKHQH LKVEFKQLQQ QREEKEQHGL QLQGEVSQLH 420
SKLLETERQL GEAHGRLKEQ RQLSSEKLMD KEQQVADLQL KLSRLEEQLK EKVTNSTELQ 480
HQLEKSKQQH QEQQALQQST TAKLREAQND LEQVLRQIGD KDQKIQNLEA LLQKSKENIS 540
LLEKEREDLY AKIQAGEGET AVLNQLQEKN HALQQQLTQL MEKLKNQSES HKQAEENLHD 600
QVQEQKAHLR AAQDRVLSLE TSVSELSSQL NESKEKVSQL DIQIKAKTEL LLSAEAAKTA 660
QRADLQNHLD TAQNALQDKQ QELNKVSAQL DQVTAKFQEK QEHCTQLESH LKDYKEKHLS 720
LEQKAEDLEG QIKKLEANNL EVKASREQAV QSLQQQRQLS TDLELRNAEL RKQLQEQKEV 780
VSHTKLDLQN KSEALENIKQ TLTKKEEEKV VLKQEFEKLS QDSEAQHKEL SDRMQAAITE 840
LMVMTAQKDA LLAELSTTKG KLSKVSDSLQ TSRSEFEKES QKGKAAVLDL EKACKELKHQ 900
LQQQTESALK EQSELKKSLE KERETSQQLM IELNSVKGEV TQAQNTLKQK EKEEQQLQGN 960
INQLKQATEQ KKKQMEALQG ELKNVTSQKA QLESKLQQQA AQAAQELAVE KGKLSALQST 1020
YDKCQADLQQ LQSDLYGKES ELLATRQDLK CVEEKLALAQ EDLISNRNQI GNQNKSIQEL 1080
QAAKAALEQD LAKKEEVLKE QSKALQDAQR EKSVKEKELV TEKSKLAEME EIKCRQEKEI 1140
AKLKEELKSH KQESIKEVTN LKDAKQLLIQ QKLELQGKVD SLKAALEQEK ERQQLMREQM 1200
RKEEEKRKEE FSEKEAKLHS EIKEKEAGVK KHEENEAKLT MQVTTLNENL GTVKKEWQSS 1260
QRRVSELEKQ TDDLRGEIAV LEATVQNNQD ERRALLERCL KGEGEIEKLQ TKVLELQRKL 1320
DNTTAAVQEL GRENQSLQIK HTQALNRKWA EDNEVQNCMS CGKCFSVTVR RHHCRQCGNI 1380
FCAECSAKNA LTPSSKKPVR VCDACFNDLQ G 1411 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0055037; C:recycling endosome; IDA:RGD.
 GO:0005969; C:serine-pyruvate aminotransferase complex; IEA:Compara.
 GO:0005545; F:1-phosphatidylinositol binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006897; P:endocytosis; IEA:Compara.
 GO:0006906; P:vesicle fusion; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE 
SMART
 SM00064; FYVE
 SM00355; ZnF_C2H2 
PROSITE
 PS50178; ZF_FYVE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS