CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017940
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ganglioside-induced differentiation-associated protein 1 
Protein Synonyms/Alias
 GDAP1 
Gene Name
 GDAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47VRLVIAEKALKCEEHubiquitination[1, 2]
113TPRLMPDKESMYYPRubiquitination[2]
172GNTESELKKLAEENPubiquitination[1, 3]
173NTESELKKLAEENPDubiquitination[1, 2, 3]
188LQEAYIAKQKRLKSKubiquitination[1, 2, 3]
190EAYIAKQKRLKSKLLubiquitination[3]
203LLDHDNVKYLKKILDacetylation[4, 5]
203LLDHDNVKYLKKILDubiquitination[2, 3]
207DNVKYLKKILDELEKubiquitination[3, 6]
214KILDELEKVLDQVETubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Regulates the mitochondrial network by promoting mitochondrial fission. 
Sequence Annotation
 DOMAIN 24 105 GST N-terminal.
 DOMAIN 153 309 GST C-terminal.
 REGION 320 358 Required for mitochondrial localization.
 MOD_RES 203 203 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Membrane; Mitochondrion; Mitochondrion outer membrane; Neuropathy; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MAERQEEQRG SPPLRAEGKA DAEVKLILYH WTHSFSSQKV RLVIAEKALK CEEHDVSLPL 60
SEHNEPWFMR LNSTGEVPVL IHGENIICEA TQIIDYLEQT FLDERTPRLM PDKESMYYPR 120
VQHYRELLDS LPMDAYTHGC ILHPELTVDS MIPAYATTRI RSQIGNTESE LKKLAEENPD 180
LQEAYIAKQK RLKSKLLDHD NVKYLKKILD ELEKVLDQVE TELQRRNEET PEEGQQPWLC 240
GESFTLADVS LAVTLHRLKF LGFARRNWGN GKRPNLETYY ERVLKRKTFN KVLGHVNNIL 300
ISAVLPTAFR VAKKRAPKVL GTTLVVGLLA GVGYFAFMLF RKRLGSMILA FRPRPNYF 358 
Gene Ontology
 GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.
 GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
 GO:0032526; P:response to retinoic acid; IEA:Compara. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR012336; Thioredoxin-like_fold. 
Pfam
  
SMART
  
PROSITE
 PS50405; GST_CTER
 PS50404; GST_NTER 
PRINTS