CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019024
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synapse-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 SYAP1 
Gene Synonyms/Alias
 PRO3113 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70NFASAATKKITESVAacetylation[1]
70NFASAATKKITESVAubiquitination[2, 3]
84AETAQTIKKSVEEGKubiquitination[2, 3]
147ILALSADKRNFLRDPubiquitination[4]
191MRFALVPKLVKEEVFacetylation[5]
194ALVPKLVKEEVFWRNubiquitination[2, 3]
210FYRVSLIKQSAQLTAubiquitination[2, 3, 4, 6]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
 DOMAIN 158 210 BSD.
 MOD_RES 248 248 Phosphothreonine.
 MOD_RES 269 269 Phosphoserine.
 MOD_RES 313 313 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 352 AA 
Protein Sequence
MFRGLSSWLG LQQPVAGGGQ PNGDAPPEQP SETVAESAEE ELQQAGDQEL LHQAKDFGNY 60
LFNFASAATK KITESVAETA QTIKKSVEEG KIDGIIDKTI IGDFQKEQKK FVEEQHTKKS 120
EAAVPPWVDT NDEETIQQQI LALSADKRNF LRDPPAGVQF NFDFDQMYPV ALVMLQEDEL 180
LSKMRFALVP KLVKEEVFWR NYFYRVSLIK QSAQLTALAA QQQAAGKEEK SNGREQDLPL 240
AEAVRPKTPP VVIKSQLKTQ EDEEEISTSP GVSEFVSDAF DACNLNQEDL RKEMEQLVLD 300
KKQEETAVLE EDSADWEKEL QQELQEYEVV TESEKRDENW DKEIEKMLQE EN 352 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara. 
Interpro
 IPR005607; BSD. 
Pfam
 PF03909; BSD 
SMART
 SM00751; BSD 
PROSITE
 PS50858; BSD 
PRINTS