CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004772
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tumor necrosis factor receptor superfamily member 1A 
Protein Synonyms/Alias
 Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD120a; Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI 
Gene Name
 TNFRSF1A 
Gene Synonyms/Alias
 TNFAR; TNFR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
242RYQRWKSKLYSIVCGubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. 
Sequence Annotation
 REPEAT 43 82 TNFR-Cys 1.
 REPEAT 83 125 TNFR-Cys 2.
 REPEAT 126 166 TNFR-Cys 3.
 REPEAT 167 196 TNFR-Cys 4.
 DOMAIN 356 441 Death.
 REGION 338 348 N-SMase activation domain (NSD).
 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 CARBOHYD 145 145 N-linked (GlcNAc...) (Potential).
 CARBOHYD 151 151 N-linked (GlcNAc...) (Potential).
 DISULFID 44 58
 DISULFID 59 72
 DISULFID 62 81
 DISULFID 84 99
 DISULFID 102 117
 DISULFID 105 125
 DISULFID 127 143
 DISULFID 146 158
 DISULFID 149 166
 DISULFID 168 179
 DISULFID 182 195
 DISULFID 185 191  
Keyword
 3D-structure; Alternative splicing; Amyloidosis; Apoptosis; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Golgi apparatus; Host-virus interaction; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 455 AA 
Protein Sequence
MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI HPQNNSICCT 60
KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD 120
RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV 180
SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK 240
SKLYSIVCGK STPEKEGELE GTTTKPLAPN PSFSPTPGFT PTLGFSPVPS STFTSSSTYT 300
PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK WEDSAHKPQS LDTDDPATLY 360
AVVENVPPLR WKEFVRRLGL SDHEIDRLEL QNGRCLREAQ YSMLATWRRR TPRREATLEL 420
LGRVLRDMDL LGCLEDIEEA LCGPAALPPA PSLLR 455 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0000139; C:Golgi membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0045121; C:membrane raft; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005031; F:tumor necrosis factor-activated receptor activity; TAS:UniProtKB.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0071392; P:cellular response to estradiol stimulus; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
 GO:0042742; P:defense response to bacterium; IEA:Compara.
 GO:0016101; P:diterpenoid metabolic process; IEA:Compara.
 GO:0009812; P:flavonoid metabolic process; IEA:Compara.
 GO:0006954; P:inflammatory response; ISS:UniProtKB.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IMP:BHF-UCL.
 GO:0032715; P:negative regulation of interleukin-6 production; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.
 GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Compara.
 GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein; IMP:BHF-UCL.
 GO:0006693; P:prostaglandin metabolic process; IEA:InterPro.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara.
 GO:0043279; P:response to alkaloid; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0033013; P:tetrapyrrole metabolic process; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR001368; TNFR/NGFR_Cys_rich_reg.
 IPR020419; TNFR_1A. 
Pfam
 PF00531; Death
 PF00020; TNFR_c6 
SMART
 SM00005; DEATH
 SM00208; TNFR 
PROSITE
 PS50017; DEATH_DOMAIN
 PS00652; TNFR_NGFR_1
 PS50050; TNFR_NGFR_2 
PRINTS
 PR01918; TNFACTORR1A.