UniProt Accession

 DAP1_MOUSE; Q91XC8 

Genbank Protein ID

 BC010828; BC024876; BC057669 

Genbank Nucleotide ID

 AAH10828.1; AAH24876.1; AAH57669.1 

Protein Name

 Death-associated protein 1 

Protein Synonyms/Alias

 DAP-1 

Gene Name

 Dap 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	GGMRIVQKHPHTGDG	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 3 3 Phosphoserine; by MTOR (By similarity).
 MOD_RES 49 49 Phosphoserine (By similarity).
 MOD_RES 50 50 Phosphothreonine.
 MOD_RES 51 51 Phosphoserine; by MTOR (By similarity).
 MOD_RES 91 91 Phosphoserine (By similarity).  

Keyword

 Acetylation; Apoptosis; Autophagy; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 102 AA 

Protein Sequence

Gene Ontology

 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0097190; P:apoptotic signaling pathway; IEA:Compara.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0034198; P:cellular response to amino acid starvation; IEA:Compara.
 GO:0010507; P:negative regulation of autophagy; IEA:Compara.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. 

Interpro

 IPR024130; DAP1/DAPL1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS