CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015014
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MutS protein homolog 5 
Protein Synonyms/Alias
  
Gene Name
 Msh5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
782IRSGKPVKPMHELVRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity). 
Sequence Annotation
 NP_BIND 589 596 ATP (Potential).  
Keyword
 ATP-binding; Complete proteome; DNA-binding; Meiosis; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 831 AA 
Protein Sequence
MAFRATPGRT PPGPGPGVPS ASFSSPQPAM AAPGGIEEED EEEPAEIHLC VLWSSGYLGI 60
AYYDTSDSTI HFMPDAPDHE SLKLLQRVLD EINPQSVVTS AKQDEAMTQF LGKLASQEHR 120
EPKRPEIILL PSVDFGPEIS KQRLLSGNYS FISESMTATE KILFLSSIIP FDCVLTVRAL 180
GGLLKFLSRR RVGVELEDYS VGVPILGFKK FVLTHLVSID QDTYSVLQIF KSESHPSVYK 240
VASGLKEGLS LFGILNRCRC RWGQKLLRLW FTRPTRELRE LNSRLDVIEF FLMPQNLDMA 300
QMMHRLLSHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA LGLRDACRSL PQSIQLFRDI 360
TQEFSDDLHH IASLIGKVVD FEESLAENRF TVLPNIDPEI DAKKRRLMGL PSFLTEVAQK 420
ELENLDSCIP SCSVIYIPLI GFLLSIPRLS FMVEASDFEI EGLDFMFLSE DKLHYRSART 480
KELDALLGDL HCEIRDQEML LMHQLQCQVL ARAPVLTRVL DLASRLDVLL ALASAARDYG 540
YSRPHYSPCI QGVRIKNGRH PLMELCARTF VPNSTDCGGD QGRVKVITGP NSSGKSIYLK 600
QVGLITFMAL VGSFVPAEEA EIGVIDAIFT RIHSCESISL GLSTFMIDLN QVAKAVNNAT 660
EHSLVLIDEF GKGTNSVDGL ALLTAVLRHW LALGPSCPHI FVATNFLSLV QLQLLPQGPL 720
VQYLTMETCE DGNDLVFFYQ LCHGVASASH ASYTAAQAGL PDPLIARGKE VSDSIRSGKP 780
VKPMHELVRR TQMENCQALV DKFLKLDLED PSLDLDIFIS QEVLPAATTI L 831 
Gene Ontology
 GO:0000795; C:synaptonemal complex; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008094; F:DNA-dependent ATPase activity; IBA:RefGenome.
 GO:0030983; F:mismatched DNA binding; IBA:RefGenome.
 GO:0051026; P:chiasma assembly; IBA:RefGenome.
 GO:0007292; P:female gamete generation; IEA:Compara.
 GO:0045143; P:homologous chromosome segregation; IBA:RefGenome.
 GO:0006298; P:mismatch repair; IEA:InterPro.
 GO:0007131; P:reciprocal meiotic recombination; IBA:RefGenome. 
Interpro
 IPR000432; DNA_mismatch_repair_MutS_C.
 IPR007861; DNA_mismatch_repair_MutS_clamp.
 IPR007696; DNA_mismatch_repair_MutS_core.
 IPR027417; P-loop_NTPase. 
Pfam
 PF05192; MutS_III
 PF05190; MutS_IV
 PF00488; MutS_V 
SMART
 SM00534; MUTSac
 SM00533; MUTSd 
PROSITE
 PS00486; DNA_MISMATCH_REPAIR_2 
PRINTS