CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphate carrier protein, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 SLC25A3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89VVPLDLVKCRMQVDPmethylation[1]
89VVPLDLVKCRMQVDPubiquitination[2]
98RMQVDPQKYKGIFNGacetylation[3]
98RMQVDPQKYKGIFNGubiquitination[4, 5, 6]
100QVDPQKYKGIFNGFSubiquitination[4]
111NGFSVTLKEDGVRGLubiquitination[4]
120DGVRGLAKGWAPTFLubiquitination[4]
205TLRDAAPKMYKEEGLubiquitination[4, 5, 6]
208DAAPKMYKEEGLKAFacetylation[3, 7]
208DAAPKMYKEEGLKAFubiquitination[4, 5, 6]
213MYKEEGLKAFYKGVAubiquitination[4, 5]
217EGLKAFYKGVAPLWMacetylation[3]
217EGLKAFYKGVAPLWMubiquitination[4, 6]
233QIPYTMMKFACFERTubiquitination[4]
246RTVEALYKFVVPKPRubiquitination[4]
251LYKFVVPKPRSECSKubiquitination[4]
317PEMPESLKKKLGLTQubiquitination[5]
319MPESLKKKLGLTQ**ubiquitination[5]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 324 AA 
Protein Sequence
MFSSVAHLAR ANPFNTPHLQ LVHDGLGDLR SSSPGPTGQP RRPRNLAAAA VEEYSCEFGS 60
AKYYALCGFG GVLSCGLTHT AVVPLDLVKC RMQVDPQKYK GIFNGFSVTL KEDGVRGLAK 120
GWAPTFLGYS MQGLCKFGFY EVFKVLYSNM LGEENTYLWR TSLYLAASAS AEFFADIALA 180
PMEAAKVRIQ TQPGYANTLR DAAPKMYKEE GLKAFYKGVA PLWMRQIPYT MMKFACFERT 240
VEALYKFVVP KPRSECSKPE QLVVTFVAGY IGVWKGLFAR IIMIGTLTAL QWFIYDSVKV 300
YFRLPRPPPP EMPESLKKKL GLTQ 324 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS