CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029970
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Interleukin-1 receptor-associated kinase 1 
Protein Synonyms/Alias
  
Gene Name
 Irak1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
372FSRFAGAKASQSSTVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 750 AA 
Protein Sequence
MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 60
RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPVVP PSTAAPRPSS 120
ISAGSEAGDW SPRKLQSSAS TFLSPAFPGS QTHSESELLQ VPLPVSLGPP LPSSAPSSTK 180
QSSPESPVSG LQRAHPSPFC WPFCEISQGT CNFSEELRIG EGGFGCVYRA VMRNTTYAVK 240
RLKEEADLEW TMVKQSFLTE VEQLSRFRHP NIVDFAGYCA ESGLYCLVYG FLPNGSLEDQ 300
LHLQTQACSP LSWPQRLDIL LGTARAIQFL HQDSPSLIHG DIKSSNVLLD ERLMPKLGDF 360
GLARFSRFAG AKASQSSTVA RTSTVRGTLA YLPEEYIKTG RLAVDTDTFS FGVVILETLA 420
GQRAVRTQGA KTKYLKDLIE DEAEEAGVTL KSTQPTLWVG VATDAWAAPI AAQIYKKHLD 480
SRPGPCPPQL GLALAQLACC CMHRRAKKRP PMTQRQNSQH SLLALWLYLG RCSVELSGKG 540
LLLCWMSLRS QEQVYKRLEG LQAGPPWELE VAGHGSPSPQ ENSYMSTTGS AQSGDEPWQP 600
LVVTTRAPAQ AAQQLQRSPN QPVESDESVP GLSATLHSWH LTPGSHPSPA SFREASCTQG 660
GTTRESSVRS SPGFQPTTME GSPTGSSSLL SSEPPQIIIN PARQKMVQKL ALYEEGVLDS 720
LQLLSSGFFP GLDLEPEKSQ GPEESDEFQS 750 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; IDA:MGI.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0070498; P:interleukin-1-mediated signaling pathway; IDA:MGI.
 GO:0007254; P:JNK cascade; IEA:Compara.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:MGI.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:MGI.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IDA:MGI.
 GO:0051259; P:protein oligomerization; IEA:Compara.
 GO:0001959; P:regulation of cytokine-mediated signaling pathway; IEA:Compara.
 GO:0032494; P:response to peptidoglycan; IDA:MGI.
 GO:0034134; P:toll-like receptor 2 signaling pathway; IDA:MGI.
 GO:0034142; P:toll-like receptor 4 signaling pathway; IDA:MGI. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00531; Death
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS