CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013505
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PAB-dependent poly(A)-specific ribonuclease subunit 3 
Protein Synonyms/Alias
 hPan3 
Gene Name
 PAN3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
282NADAYFTKRKWGQHEubiquitination[1]
333CRVMDPTKILITGKTubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity. 
Sequence Annotation
 DOMAIN 492 754 Protein kinase.
 ZN_FING 43 71 C3H1-type.
 REGION 1 491 Interaction with polyadenylate-binding
 REGION 492 887 Interaction with PAN2.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nonsense-mediated mRNA decay; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 887 AA 
Protein Sequence
MKLTDSTKGW IVWAALDSSM RGMSLSAGSS PLHSPKITPH TSPAPRRRSH TPNPASYMVP 60
SSASTSVNNP VSQTPSSGQV IQKETVGGTT YFYTDTTPAP LTGMVFPNYH IYPPTAPHVA 120
YMQPKANAPS FFMADELRQE LINRHLITMA QIDQADMPAV PTEVDSYHSL FPLEPLPPPN 180
RIQKSSNFGY ITSCYKAVNS KDDLPYCLRR IHGFRLVNTK CMVLVDMWKK IQHSNIVTLR 240
EVFTTKAFAE PSLVFAYDFH AGGETMMSRH FNDPNADAYF TKRKWGQHEG PLPRQHAGLL 300
PESLIWAYIV QLSSALRTIH TAGLACRVMD PTKILITGKT RLRVNCVGVF DVLTFDNSQN 360
NNPLALMAQY QQADLISLGK VVLALACNSL AGIQRENLQK AMELVTINYS SDLKNLILYL 420
LTDQNRMRSV NDIMPMIGAR FYTQLDAAQM RNDVIEEDLA KEVQNGRLFR LLAKLGTINE 480
RPEFQKDPTW SETGDRYLLK LFRDHLFHQV TEAGAPWIDL SHIISCLNKL DAGVPEKISL 540
ISRDEKSVLV VTYSDLKRCF ENTFQELIAA ANGQL 575 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0000932; C:cytoplasmic mRNA processing body; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031251; C:PAN complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:Compara.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
 GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
 GO:0010606; P:positive regulation of cytoplasmic mRNA processing body assembly; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR000571; Znf_CCCH. 
Pfam
  
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS50103; ZF_C3H1 
PRINTS