CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Soluble lytic murein transglycosylase 
Protein Synonyms/Alias
 Exomuramidase; Peptidoglycan lytic exotransglycosylase; Slt70 
Gene Name
 slt 
Gene Synonyms/Alias
 sltY; b4392; JW4355 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
41RSRYAQIKQAWDNRQacetylation[1]
436SEWANLVKSKSKTEQacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division. 
Sequence Annotation
 REGION 492 582 Slt-type domain.
 ACT_SITE 505 505
 DISULFID 133 166  
Keyword
 3D-structure; Cell wall biogenesis/degradation; Complete proteome; Direct protein sequencing; Disulfide bond; Lyase; Periplasm; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 645 AA 
Protein Sequence
MEKAKQVTWR LLAAGVCLLT VSSVARADSL DEQRSRYAQI KQAWDNRQMD VVEQMMPGLK 60
DYPLYPYLEY RQITDDLMNQ PAVTVTNFVR ANPTLPPART LQSRFVNELA RREDWRGLLA 120
FSPEKPGTTE AQCNYYYAKW NTGQSEEAWQ GAKELWLTGK SQPNACDKLF SVWRASGKQD 180
PLAYLERIRL AMKAGNTGLV TVLAGQMPAD YQTIASAIIS LANNPNTVLT FARTTGATDF 240
TRQMAAVAFA SVARQDAENA RLMIPSLAQA QQLNEDQIQE LRDIVAWRLM GNDVTDEQAK 300
WRDDAIMRSQ STSLIERRVR MALGTGDRRG LNTWLARLPM EAKEKDEWRY WQADLLLERG 360
REAEAKEILH QLMQQRGFYP MVAAQRIGEE YELKIDKAPQ NVDSALTQGP EMARVRELMY 420
WNLDNTARSE WANLVKSKSK TEQAQLARYA FNNQWWDLSV QATIAGKLWD HLEERFPLAY 480
NDLFKRYTSG KEIPQSYAMA IARQESAWNP KVKSPVGASG LMQIMPGTAT HTVKMFSIPG 540
YSSPGQLLDP ETNINIGTSY LQYVYQQFGN NRIFSSAAYN AGPGRVRTWL GNSAGRIDAV 600
AFVESIPFSE TRGYVKNVLA YDAYYRYFMG DKPTLMSATE WGRRY 645 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoliWiki.
 GO:0016837; F:carbon-oxygen lyase activity, acting on polysaccharides; IEA:EC.
 GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
 GO:0008933; F:lytic transglycosylase activity; IDA:EcoliWiki.
 GO:0000270; P:peptidoglycan metabolic process; IEA:InterPro. 
Interpro
 IPR023346; Lysozyme-like_dom.
 IPR016026; Lytic_TGlyclase_suprhlx_U/L.
 IPR008258; Lytic_TGlycosylase-like_cat.
 IPR012289; Lytic_TGlycosylase_superhlx_L.
 IPR008939; Lytic_TGlycosylase_superhlx_U.
 IPR000189; Transglyc_AS. 
Pfam
 PF01464; SLT 
SMART
  
PROSITE
 PS00922; TRANSGLYCOSYLASE 
PRINTS