CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041044
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Coatomer subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Copa 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46RMCTLIDKFDEHDGPacetylation[1, 2]
46RMCTLIDKFDEHDGPubiquitination[3]
61VRGIDFHKQQPLFVSacetylation[1]
61VRGIDFHKQQPLFVSubiquitination[3]
74VSGGDDYKIKVWNYKubiquitination[3]
170DISGLRKKNLSPGAVubiquitination[3]
271ILSNSEDKSIRVWDMacetylation[4]
362MQLRSGSKFPVFNMSubiquitination[3]
398YDLYTIPKDADSQNPubiquitination[3]
438RMHSLLIKNLKNEITacetylation[1]
441SLLIKNLKNEITKKIubiquitination[3]
447LKNEITKKIQVPNCDubiquitination[3]
480TLFDVQQKRTLASVKacetylation[5]
480TLFDVQQKRTLASVKubiquitination[3]
583PIYVTRVKGNNVYCLubiquitination[3]
607TIDPTEFKFKLALINacetylation[5]
607TIDPTEFKFKLALINubiquitination[3]
609DPTEFKFKLALINRKacetylation[1]
609DPTEFKFKLALINRKubiquitination[3]
616KLALINRKYDEVLHMacetylation[1]
628LHMVRNAKLVGQSIIubiquitination[3]
640SIIAYLQKKGYPEVAacetylation[1]
640SIIAYLQKKGYPEVAubiquitination[3]
736MKIAEIRKDMSGHYQubiquitination[3]
759SERVRILKNCGQKSLubiquitination[3]
834FEGSIASKGKGGALAubiquitination[3]
1002NWKDAGLKNGVPAVGubiquitination[3]
1037KFEEAVEKFRSILLSacetylation[1]
1037KFEEAVEKFRSILLSubiquitination[3]
1143RLLELGPKPEVAQQTacetylation[5]
1193YRGKPVEKCPLSGACacetylation[1]
1193YRGKPVEKCPLSGACubiquitination[3]
1220TTVTEIGKDVIGLRIacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1233 AA 
Protein Sequence
MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW 120
NWQSRTCVCV LTGHNHYVMC AQFHPSEDLV VSASLDQTVR VWDISGLRKK NLSPGAVESD 180
VRGITGVDLF GTTDAVVKHV LEGHDRGVNW AAFHPTMPLI VSGADDRQVK IWRMNESKAW 240
EVDTCRGHYN NVSCAVFHPR QELILSNSED KSIRVWDMSK RTGVQTFRRD HDRFWVLAAH 300
PNLNLFAAGH DGGMIVFKLE RERPAYAVHG NMLHYVKDRF LRQLDFNSSK DVAVMQLRSG 360
SKFPVFNMSY NPAENAVLLC TRASNLENST YDLYTIPKDA DSQNPDAPEG KRSSGLTAVW 420
VARNRFAVLD RMHSLLIKNL KNEITKKIQV PNCDEIFYAG TGNLLLRDAD SITLFDVQQK 480
RTLASVKISK VKYVIWSADM SHVALLAKHE HSCPLPLTAI VICNRKLDAL CNIHENIRVK 540
SGAWDESGVF IYTTSNHIKY AVTTGDHGII RTLDLPIYVT RVKGNNVYCL DRECRPRVLT 600
IDPTEFKFKL ALINRKYDEV LHMVRNAKLV GQSIIAYLQK KGYPEVALHF VKDEKTRFSL 660
ALECGNIEIA LEAAKALDDK NCWEKLGEVA LLQGNHQIVE MCYQRTKNFD KLSFLYLITG 720
NLEKLRKMMK IAEIRKDMSG HYQNALYLGD VSERVRILKN CGQKSLAYLS AATHGLDEEA 780
ESLKETFDPE KETIPDIDPN AKLLQPPAPI MPLDTNWPLL TVSKGFFEGS IASKGKGGAL 840
AADIDIDTVG TEGWGEDAEL QLDEDGFVEA PEGLGEDVLG KGQEEGGGWD VEEDLELPPE 900
LDVPSGVSGS AEDGFFVPPT KGTSPTQIWC NNSQLPVDHI LAGSFETAMR LLHDQVGVIQ 960
FGPYKQLFLQ TYARGRTTYQ ALPCLPSMYS YPNRNWKDAG LKNGVPAVGL KLNDLIQRLQ 1020
LCYQLTTVGK FEEAVEKFRS ILLSVPLLVV DNKQEIAEAQ QLITICREYI VGLCMEIERK 1080
KLPKETLDQQ KRICEMAAYF THSNLQPVHM ILVLRTALNL FFKLKNFKTA ATFARRLLEL 1140
GPKPEVAQQT RKILSACEKN PTDACQLNYD MHNPFDICAA SYRPIYRGKP VEKCPLSGAC 1200
YSPEFKGQIC RVTTVTEIGK DVIGLRISPL QFR 1233 
Gene Ontology
 GO:0030126; C:COPI vesicle coat; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR016391; Coatomer_asu.
 IPR010714; Coatomer_asu_C.
 IPR006692; Coatomer_WD-assoc_reg.
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF04053; Coatomer_WDAD
 PF06957; COPI_C
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.