UniProt Accession

 ACBP_HUMAN; P07108; B8ZWD2; B8ZWD6; B8ZWD7; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8 

Genbank Protein ID

 M14200; M15887; FM213123; FM213124; FM213125; FM213126; FM213127; FM213128; FM213131; CR456956; AC016736; CH471103; BC006466; BC062996; AM000001 

Genbank Nucleotide ID

 AAA52171.1; AAA35788.1; CAR82405.1; CAR82406.1; CAR82407.1; CAR82408.1; CAR82409.1; CAR82410.1; CAR82414.1; CAG33237.1; AAY14873.1; EAW95214.1; AAH62996.1; CAJ00736.1 

Protein Name

 Acyl-CoA-binding protein 

Protein Synonyms/Alias

 ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP 

Gene Name

 DBI 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
114	GMLDFTGKAKWDAWN	ubiquitination	[1]
116	LDFTGKAKWDAWNEL	ubiquitination	[1]
124	WDAWNELKGTSKEDA	ubiquitination	[1]
138	AMKAYINKVEELKKK	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. 

Sequence Annotation

 DOMAIN 2 87 ACB.
 REGION 29 33 Acyl-CoA binding.
 BINDING 14 14 Acyl-CoA.
 BINDING 55 55 Acyl-CoA.
 BINDING 74 74 Acyl-CoA.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 8 8 N6-acetyllysine.
 MOD_RES 19 19 N6-acetyllysine.
 MOD_RES 29 29 Phosphotyrosine.
 MOD_RES 55 55 N6-acetyllysine; alternate.
 MOD_RES 55 55 N6-malonyllysine; alternate.
 MOD_RES 77 77 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative promoter usage; Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Lipid-binding; Phosphoprotein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 87 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030156; F:benzodiazepine receptor binding; TAS:ProtInc.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0006810; P:transport; IEA:UniProtKB-KW.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara. 

Interpro

 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 

Pfam

 PF00887; ACBP 

SMART

  

PROSITE

 PS00880; ACB_1
 PS51228; ACB_2 

PRINTS

 PR00689; ACOABINDINGP.