| Tag | Content |
|---|
| CPLM ID | CPLM-021764 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transducin-like enhancer protein 3 |
Protein Synonyms/Alias | rTLE3 |
Gene Name | Tle3 |
Gene Synonyms/Alias | Esp3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 225 | ADYSMEAKKRKAEEK | acetylation | [1] | | 343 | GLRSMPGKPPGMDPI | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). |
Sequence Annotation | REPEAT 476 514 WD 1.
REPEAT 522 561 WD 2.
REPEAT 566 605 WD 3.
REPEAT 608 647 WD 4.
REPEAT 649 688 WD 5.
REPEAT 690 729 WD 6.
REPEAT 731 763 WD 7.
REGION 199 268 CCN domain.
MOTIF 225 228 Nuclear localization signal (Potential).
MOD_RES 203 203 Phosphoserine (By similarity).
MOD_RES 207 207 Phosphoserine (By similarity).
MOD_RES 217 217 Phosphoserine (By similarity).
MOD_RES 240 240 Phosphoserine (By similarity).
MOD_RES 245 245 Phosphoserine (By similarity).
MOD_RES 259 259 Phosphothreonine (By similarity).
MOD_RES 263 263 Phosphoserine (By similarity).
MOD_RES 267 267 Phosphoserine (By similarity).
MOD_RES 286 286 Phosphoserine (By similarity).
MOD_RES 312 312 Phosphothreonine (By similarity).
MOD_RES 317 317 Phosphoserine (By similarity).
MOD_RES 319 319 Phosphothreonine (By similarity).
MOD_RES 321 321 Phosphothreonine (By similarity).
MOD_RES 328 328 Phosphothreonine (By similarity).
MOD_RES 334 334 Phosphothreonine (By similarity).
MOD_RES 410 410 Phosphoserine (By similarity). |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 764 AA |
Protein Sequence | MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLAV 180
KDEKNHHELD HRERESSTNN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 240
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARGLK KDAPTSPASV ASSSSTPSSK 300
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISL 360
TSSYAAPFAM MSHHEMNGSL TSPSAYAGLH NIPSQMSAAA AAAAAAYGRS PMVGFDPHPP 420
MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR QINTLSHGEV 480
VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI 540
VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCCSDG NIAVWDLHNQ 600
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC 660
PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR 720
TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY 764 |
Gene Ontology | GO:0005634; C:nucleus; IDA:BHF-UCL. GO:0006355; P:regulation of transcription, DNA-dependent; IDA:RGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |