CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040049
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Frizzled-6 
Protein Synonyms/Alias
  
Gene Name
 FZD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
203TEWAGFFKRNRKRDPubiquitination[1]
331SGEQVDGKGQAGSVSubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Developmental protein; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 401 AA 
Protein Sequence
MTRVLPRWKW SCEAIEQKAV WFHAVAWGTP GFLTVMLLAM NKVEGDNISG VCFVGLYDLD 60
ASRYFVLLPL CLCVFVGLSL LLAGIISLNH VRQVIQHDGR NQEKLKKFMI RIGVFSGLYL 120
VPLVTLLGCY VYEQVNRITW EITWVSDHCR QYHIPCPYQA KAKARPELAL FMIKYLMTLI 180
VGISAVFWVG SKKTCTEWAG FFKRNRKRDP ISESRRVLQE SCEFFLKHNS KVKHKKKHYK 240
PSSHKLKVIS KSMGTSTGAT ANHGTSAVAI TSHDYLGQET LTEIQTSPET SMREVKADGA 300
STPRLREQDC GEPASPAASI SRLSGEQVDG KGQAGSVSES ARSEGRISPK SDITDTGLAQ 360
SNNLQVPSSS EPSSLKGSTS LLVHPVSGVR KEQGGGCHSD T 401 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0042813; F:Wnt-activated receptor activity; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR000539; Frizzled.
 IPR015526; Frizzled/SFRP.
 IPR026543; FZD6.
 IPR017981; GPCR_2-like. 
Pfam
 PF01534; Frizzled 
SMART
  
PROSITE
 PS50261; G_PROTEIN_RECEP_F2_4 
PRINTS
 PR00489; FRIZZLED.