UniProt Accession

 NDUV1_HUMAN; P49821; O60924; O60940; Q16104; Q6IBR3; Q96BF8; Q96HS7 

Genbank Protein ID

 Y17379; Y17380; Y17381; Y17382; Y17383; AF053069; AF053070; AF092131; CR456739; CH471076; BC008146; BC015645; AH004147; S67973 

Genbank Nucleotide ID

 CAA76757.1; CAA76757.1; CAA76757.1; CAA76757.1; CAA76757.1; AAC39750.1; AAC39722.1; AAD40373.1; CAG33020.1; EAW74655.1; AAH08146.1; AAH15645.1; AAB24883.1; AAB29698.2 

Protein Name

 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 

Protein Synonyms/Alias

 Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit 

Gene Name

 NDUFV1 

Gene Synonyms/Alias

 UQOR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
71	KTKEILLKGPDWILG	ubiquitination	[1, 2]
81	DWILGEIKTSGLRGR	ubiquitination	[1]
126	EGEPGTCKDREILRH	ubiquitination	[2]
137	ILRHDPHKLLEGCLV	ubiquitination	[2]
365	DRSTDIVKAIARLIE	ubiquitination	[2]
375	ARLIEFYKHESCGQC	ubiquitination	[2]
394	EGVDWMNKVMARFVR	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 

Sequence Annotation

 NP_BIND 87 96 NAD(H) (By similarity).
 NP_BIND 199 247 FMN (By similarity).
 METAL 379 379 Iron-sulfur (4Fe-4S) (Potential).
 METAL 382 382 Iron-sulfur (4Fe-4S) (Potential).
 METAL 385 385 Iron-sulfur (4Fe-4S) (Potential).
 METAL 425 425 Iron-sulfur (4Fe-4S) (Potential).
 MOD_RES 81 81 N6-acetyllysine (By similarity).
 MOD_RES 104 104 N6-acetyllysine (By similarity).
 MOD_RES 375 375 N6-acetyllysine (By similarity).  

Keyword

 4Fe-4S; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Electron transport; Flavoprotein; FMN; Iron; Iron-sulfur; Leigh syndrome; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
 IPR019575; NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
 IPR011537; NADH-UbQ_OxRdtase_suF.
 IPR011538; NADH_UbQ_OxRdtase_51kDa_su.
 IPR019554; Soluble_ligand-bd. 

Pfam

 PF01512; Complex1_51K
 PF10589; NADH_4Fe-4S
 PF10531; SLBB 

SMART

 SM00928; NADH_4Fe-4S 

PROSITE

 PS00644; COMPLEX1_51K_1
 PS00645; COMPLEX1_51K_2 

PRINTS