UniProt Accession

 ICAM3_HUMAN; P32942; Q6PD68 

Genbank Protein ID

 S50015; X69711; X69819; DQ217937; CH471106; BC058903 

Genbank Nucleotide ID

 AAB24331.2; CAA49369.1; CAA49473.1; ABB01007.1; EAW84092.1; AAH58903.1 

Protein Name

 Intercellular adhesion molecule 3 

Protein Synonyms/Alias

 ICAM-3; CDw50; ICAM-R; CD50 

Gene Name

 ICAM3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
401	LRVLYGPKIDRATCP	ubiquitination	[1]
412	ATCPQHLKWKDKTRH	ubiquitination	[1]
414	CPQHLKWKDKTRHVL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. 

Sequence Annotation

 DOMAIN 46 103 Ig-like C2-type 1.
 DOMAIN 132 197 Ig-like C2-type 2.
 DOMAIN 234 301 Ig-like C2-type 3.
 DOMAIN 329 382 Ig-like C2-type 4.
 DOMAIN 416 469 Ig-like C2-type 5.
 CARBOHYD 52 52 N-linked (GlcNAc...).
 CARBOHYD 84 84 N-linked (GlcNAc...).
 CARBOHYD 87 87 N-linked (GlcNAc...).
 CARBOHYD 91 91 N-linked (GlcNAc...); atypical.
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...).
 CARBOHYD 134 134 N-linked (GlcNAc...).
 CARBOHYD 206 206 N-linked (GlcNAc...).
 CARBOHYD 264 264 N-linked (GlcNAc...) (Potential).
 CARBOHYD 295 295 N-linked (GlcNAc...).
 CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
 CARBOHYD 320 320 N-linked (GlcNAc...) (Potential).
 CARBOHYD 363 363 N-linked (GlcNAc...).
 CARBOHYD 389 389 N-linked (GlcNAc...) (Potential).
 CARBOHYD 453 453 N-linked (GlcNAc...) (Potential).
 CARBOHYD 457 457 N-linked (GlcNAc...) (Potential).
 DISULFID 53 96
 DISULFID 139 190 Potential.
 DISULFID 241 294 Potential.
 DISULFID 336 375 Potential.
 DISULFID 423 462 Potential.  

Keyword

 3D-structure; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 547 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005178; F:integrin binding; TAS:ProtInc.
 GO:0016337; P:cell-cell adhesion; IEA:InterPro.
 GO:0050776; P:regulation of immune response; TAS:Reactome. 

Interpro

 IPR003988; ICAM.
 IPR013768; ICAM_N.
 IPR003987; ICAM_VCAM_N.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub. 

Pfam

 PF03921; ICAM_N 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS

 PR01473; ICAM.
 PR01472; ICAMVCAM1.