| Tag | Content |
|---|
| CPLM ID | CPLM-023392 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Enhancer of mRNA-decapping protein 4 homolog |
Protein Synonyms/Alias | |
Gene Name | Ge-1 |
Gene Synonyms/Alias | CG6181 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 965 | KLMEQYLKRYENEHK | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets. |
Sequence Annotation | REPEAT 309 348 WD 1.
REPEAT 363 406 WD 2.
MOD_RES 32 32 Phosphoserine.
MOD_RES 561 561 Phosphoserine.
MOD_RES 563 563 Phosphothreonine.
MOD_RES 576 576 Phosphoserine.
MOD_RES 581 581 Phosphothreonine.
MOD_RES 759 759 Phosphoserine.
MOD_RES 762 762 Phosphoserine.
MOD_RES 763 763 Phosphoserine.
MOD_RES 1207 1207 Phosphoserine.
MOD_RES 1211 1211 Phosphothreonine.
MOD_RES 1317 1317 Phosphothreonine.
MOD_RES 1320 1320 Phosphotyrosine. |
Keyword | 3D-structure; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1354 AA |
Protein Sequence | MLIALFALAH LPIFRKTPLS ASSSPPPSVH RSPRCGKAST AYHPPPADAC ISITASAIDA 60
ASGMSNSAEQ DKPIAANGNA AEPQEIEVIH FQAQEKQCCR VIRSNKTKVL TSGGVHTRGS 120
SKVKLKNIVD YKWERKYYYP GHLVAVHRDG KHLAYAINVN NKATGMEGMV RVCNIATSMR 180
ALIKGMSGEV LDLQFAHTDC ERILAVIDVS SLFVYKVDQI EGNLLCNLVL KVEDPIANYV 240
PEYDMVSWCP YVCSSSATVP INDDDDENQL LIWSRSSQFQ CFQVKMIVSE HGRGKIQPAA 300
LESGYLKIEE DSLITCAALS PDGTTVAAAC ADGLVRFYQI YLFDVRNHRC LHEWKPHDGK 360
KVCSLFFLDN INKPVEESYW QHVITTSDAN TEIKLWNCSL WKCLQTINVV ASPSSLQPRN 420
FIAGIDRSAN YLVLSCLDSL AVYVMQIGST GGADSENRSS DSEGEGCDTS KRIQNVAEFK 480
LSSGILSFSI VNASMRRVKN SIESYYPIEE PDDFDDDSNS TSALVLHMFV VQAKSLQECQ 540
IIYQPCVAEK TERSSLNSKR SQTPEDNLLI KEEPESPNSG TVGAVQLDAL FAKSAKRAST 600
GSSSAMVAVA AAAAAAPSAI LQDATKEAAK SESPQLSSAY TQQVNLMTPD AFSASGTAAA 660
AAVFVSTSTT TSIGTDSSTT TSGQDRSIDS AVLQTIRMLA TVTSKTSENP NAEVLLNLMN 720
NTLIEDREQQ KLKEKLDARK KFIAIDRNPE RNVAENLASG SSSPSREVQE IMATQDDADA 780
YEAELENLDD DDDDEEEELA NSSPLPEAVD GTWPIVKLSS HSAELQNAAQ IMSQAVQNTN 840
NGNVPPTLGG GHNNNTSVGS NSNNNTATTL STSNTSSSNN AGGTCVDSSG TGELNAKMEL 900
LIDLVKAQSK QINKLENEVN KLQKQQEAAA ALHSKQDTSL EPKNLSQLAY KIEMQLSKLM 960
EQYLKRYENE HKKKLTEFLA ARESQNRELR DSVLQVLNQY VMNHFTDIIG NVLNMELQRQ 1020
LLPRVNANMD QLQAQMQVEI VQKLSVFDKT VKENIAQVCK SKQFLDTFGK SVLIGVQTSL 1080
QTAFIESMSS TLIPAYEKSS QNMFKQLHDA FSVGIKDFMV QFNTYLQHMP QPQAGSGNTE 1140
EINNKLSMLK QLVESSLHKH RTELTDAMLE TQREVKSLEI LLARQVQETI RAELRKHMEA 1200
QNVAMRSQAA TPAPPYDLRD SIKQLLMAGQ INKAFHQALL ANDLGLVEFT LRHTDSNQAF 1260
APEGCRLEQK VLLSLIQQIS ADMTNHNELK QRYLNEALLA INMADPITRE HAPKVLTELY 1320
RNCQQFIKNS PKNSQFSNVR LLMKAIITYR DQLK 1354 |
Gene Ontology | GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB. GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:FlyBase. GO:0050832; P:defense response to fungus; IMP:FlyBase. GO:0006402; P:mRNA catabolic process; IMP:UniProtKB. GO:0045451; P:pole plasm oskar mRNA localization; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |