CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032434
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Unconventional myosin-VIIb 
Protein Synonyms/Alias
  
Gene Name
 MYO7B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******MKYLLNFIGubiquitination[1]
45WLELQAVKSKKHIPIubiquitination[1, 2]
140PWRIYFRKEFFTPWHubiquitination[1]
176SGEYSFEKEEELVELubiquitination[1]
199LGASAESKAVQELLPubiquitination[1, 2]
212LPSCIPHKLYRTKPPubiquitination[1, 2, 3]
217PHKLYRTKPPDRWASubiquitination[1]
232LVTAACAKAPYTQKQubiquitination[1, 2]
238AKAPYTQKQVTPLAVubiquitination[1, 3]
366AMALQDRKATDDTTLubiquitination[1, 2, 3]
377DTTLLAFKKGDLLVLubiquitination[1, 3]
378TTLLAFKKGDLLVLTubiquitination[1, 2]
386GDLLVLTKKQGLLASubiquitination[1, 3]
387DLLVLTKKQGLLASEubiquitination[1, 2, 3]
406GQNDRTGKTGLVPMAubiquitination[1]
423YTIPTVTKPSAQLLSubiquitination[1]
438LLAMSPEKRKLAAQEubiquitination[1]
458PRPEEPPKEKLHTLEubiquitination[1]
477EFFRAPEKDMVSMAVubiquitination[1, 3]
508PLRQPLLKRVHANVDubiquitination[1]
606GLLPHAQKFIDTRRGubiquitination[1]
614FIDTRRGKLLAPDCSubiquitination[1]
626DCSRRIQKVLRTGPRubiquitination[1]
634VLRTGPRKQPPHQVEubiquitination[1, 2, 3]
655NVSRICHKIYFPNDTubiquitination[1]
702LFIKISDKVISQKEGubiquitination[1]
707SDKVISQKEGDFFFDubiquitination[1, 2]
724REVSDWVKKNKPQKEubiquitination[1]
725EVSDWVKKNKPQKEGubiquitination[1]
730VKKNKPQKEGAPVTLubiquitination[1]
755WLNISPGKDVNADTIubiquitination[1]
771HYHQELPKYLRGFHKubiquitination[1]
793HLAGLIYKAQFNNDRubiquitination[1]
808SQLASVPKILRELVPubiquitination[1, 2]
828LMSSEEWKKSILLAYubiquitination[1, 2]
829MSSEEWKKSILLAYDubiquitination[1]
837SILLAYDKHKDKTVEubiquitination[1]
839LLAYDKHKDKTVEEAubiquitination[1]
841AYDKHKDKTVEEAKVubiquitination[1]
847DKTVEEAKVAFLKWIubiquitination[1]
852EAKVAFLKWICRWPTubiquitination[1]
896LLIHPKTKDLLTTYPubiquitination[1]
957QLLSAMNKQRGSKAPubiquitination[1]
962MNKQRGSKAPALASTubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 969 AA 
Protein Sequence
MKYLLNFIGQ GPATYGPFCA ERLRRTYANG VRAEPPTWLE LQAVKSKKHI PIQVILATGE 60
SLTVPVDSAS TSREMCMHIA HKQGLSDHLG FSLQVAVYDK FWSLGSGRDH MMDAIARCEQ 120
MAQERGESQR QSPWRIYFRK EFFTPWHDSR EDPVSTELIY RQVLRGVWSG EYSFEKEEEL 180
VELLARHCYV QLGASAESKA VQELLPSCIP HKLYRTKPPD RWASLVTAAC AKAPYTQKQV 240
TPLAVREQVV DAARLQWPLL FSRLFEVITL SGPRLPKTQL ILAVNWKGLC FLDQQEKMLL 300
ELSFPEVMGL ATNREAQGGQ RLLLSTMHEE YEFVSPSSVA IAELVALFLE GLKERSIFAM 360
ALQDRKATDD TTLLAFKKGD LLVLTKKQGL LASENWTLGQ NDRTGKTGLV PMACLYTIPT 420
VTKPSAQLLS LLAMSPEKRK LAAQEGQFTE PRPEEPPKEK LHTLEEFSYE FFRAPEKDMV 480
SMAVLPLARA RGHLWAYSCE PLRQPLLKRV HANVDLWDIA CQIFVAILRY MGDYPSRQAW 540
PTLELTDQIF TLALQHPALQ DEVYCQILKQ LTHNSNRHSE ERGWQLLWLC TGLFPPSKGL 600
LPHAQKFIDT RRGKLLAPDC SRRIQKVLRT GPRKQPPHQV EVEAAEQNVS RICHKIYFPN 660
DTSEMLEVVA NTRVRDVCDS IATRLQLASW EGCSLFIKIS DKVISQKEGD FFFDSLREVS 720
DWVKKNKPQK EGAPVTLPYQ VYFMRKLWLN ISPGKDVNAD TILHYHQELP KYLRGFHKCS 780
REDAIHLAGL IYKAQFNNDR SQLASVPKIL RELVPENLTR LMSSEEWKKS ILLAYDKHKD 840
KTVEEAKVAF LKWICRWPTF GSAFFEVKQT SEPSYPDVIL IAINRHGVLL IHPKTKDLLT 900
TYPFTKISSW SSGSTYFHMA LGSLGRGSRL LCETSLGYKM DDLLTSYVQQ LLSAMNKQRG 960
SKAPALAST 969 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro. 
Interpro
 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR000299; FERM_domain.
 IPR000857; MyTH4_dom.
 IPR011993; PH_like_dom.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00373; FERM_M
 PF00784; MyTH4
 PF07653; SH3_2 
SMART
 SM00295; B41
 SM00139; MyTH4
 SM00326; SH3 
PROSITE
 PS50057; FERM_3
 PS51016; MYTH4
 PS50002; SH3 
PRINTS