| Tag | Content |
|---|
| CPLM ID | CPLM-014900 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeat-containing protein 16A |
Protein Synonyms/Alias | CARMIL homolog |
Gene Name | Lrrc16a |
Gene Synonyms/Alias | Carmil; Lrrc16 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 308 | AKLPKGLKHLNLSKT | ubiquitination | [1] | | 823 | SIPRTFVKNVLLEQS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization. |
Sequence Annotation | REPEAT 245 269 LRR 1.
REPEAT 275 298 LRR 2.
REPEAT 304 327 LRR 3.
REPEAT 336 363 LRR 4.
REPEAT 391 418 LRR 5.
REPEAT 423 447 LRR 6.
REPEAT 485 510 LRR 7.
REPEAT 547 570 LRR 8.
REPEAT 574 597 LRR 9.
REPEAT 658 682 LRR 10.
REPEAT 962 985 LRR 11.
REGION 962 1084 Inhibits capping activity of CAPZA2.
MOD_RES 920 920 Phosphothreonine (By similarity).
MOD_RES 972 972 Phosphoserine.
MOD_RES 1295 1295 Phosphoserine (By similarity).
MOD_RES 1319 1319 Phosphoserine (By similarity).
MOD_RES 1335 1335 Phosphoserine (By similarity).
MOD_RES 1363 1363 Phosphoserine (By similarity).
CROSSLNK 597 597 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Isopeptide bond; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1374 AA |
Protein Sequence | MTDESSDVPR ELMESIKDVI GRKIKISVKK KVKLEVKGDR VENKVLVLTS CRAFLLSARI 60
PSKLELTFSY LEIHGVICHK PAQMVVETEK CNMSMKMVSP EDVSEVLAHI GTCLRRIFPG 120
LSPLRIMKKV SMEPSERLAS LQALWDSQTL AEPGPCGGFS QMYACVCDWL GFSYKEEVQW 180
DVDTIYLTQD TRELNLQDFS HLEHRDLIPI IAALEYNQWF TKLSSKDLKL STDVCEQILR 240
VVSRSNRLEE LVLENAGLRI DFAQKLAGAL AHNPNSGLHT INLAGNSLED RGVSSLSIQF 300
AKLPKGLKHL NLSKTSLSPK GVNSLCQSLS ANPLTASTLT HLDLSGNALR GDDLSHMYNF 360
LAQPNTIVHL DLSNTECSLE MVCSALLRGC LQCLAVLNLS RSVFSHRKGK EVPPSFKQFF 420
SSSLALIQIN LSGTKLSPEP LKALLLGLAC NHSLKGVSLD LSNCELGHCL RSGGAQVLEG 480
CIAEIHNITS LDISDNGLES DLSTLIVWLS KNRSIQHLAL GKNFNNMKSK NLTPVLDNLV 540
QMIQDEDSPL QSLSLADSKL KAEVTIIINA LGSNTSLTKV DISGNGMGDM GAKMLAKALQ 600
INTKLRTVIW DKNNITAQGF QDIAVAMEKN YTLRFMPIPM YDAAQALKTN PEKTEEALQK 660
IENYLLRNHE TRKYLQEQAY RLQQGIVTST TQQMIDRICV KVQDHLNSLR ACGGDAIQED 720
LKAAERLMRD AKNSKTLLPN LYHVGGASWA GASGLSSSPI QETLESMAGE VTRVVDEQLK 780
DLLESMVDAA ETLCPNVMRK AHIRQDLIHA STEKISIPRT FVKNVLLEQS GIDILNKISE 840
VKLTVASFLS DRIVDEILDS LSSSHRKLAN HFSRLNKSLP QREDLEVELV EEKPVKRAIL 900
TVEDLTEVER LEDLDTCMMT PKSKRKSIHS RMLRPVSRAF EMEFDLDKAL EEVPIHIEDP 960
PFPSVRQEKR SSGLISELPS EEGRRLEHFT KLRPKRNKKQ QPTQAAVCTI SILPQDGEQN 1020
GLMGRVDEGV DEFFTKKVTK MDCKRSSSRS SDAHELGEGD EKKKRDSRRS GFLNLIKSRS 1080
RSERPPTVLM TEELSSPKGA MRSPPVDTTR KEIKAAEHNG APDRTEEIKT PEPLEEGPAE 1140
EAGRAERSDS RGSPQGGRRY VQVMGSGLLA EMKAKQERRA ACAQKKLGND VISQDPSSPV 1200
SCNTERLEGG ATVPKLQPGL PEARFGSGTP EKNAKAEPRV DGGCRSRSSS SMPTSPKPLL 1260
QSPKPSPSAR PSIPQKPRTA SRPEDTPDSP SGPSSPKVAL LPPILKKVSS DKERDGQNSS 1320
QSSPRSFSQE ASRRSWGPAQ EYQEQKQRSS GKDGHQGSKC SDSGEEAEKE FIFV 1374 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |