UniProt Accession

 GDIB_MOUSE; Q61598; Q541Z9; Q8C530; Q9D8M9 

Genbank Protein ID

 L36314; AK007871; AK078144; AK079690; AK090083; AK143633; AK149958; AK152250; AK153381; AK159734; AK166317; AK169299; BC055341 

Genbank Nucleotide ID

 AAA78786.1; BAB25321.1; BAC37145.1; BAC37725.1; BAC41085.1; BAE25473.1; BAE29194.1; BAE31072.1; BAE31947.1; BAE35328.1; BAE38700.1; BAE41055.1; AAH55341.1 

Protein Name

 Rab GDP dissociation inhibitor beta 

Protein Synonyms/Alias

 Rab GDI beta; GDI-3; Guanosine diphosphate dissociation inhibitor 2; GDI-2 

Gene Name

 Gdi2 

Gene Synonyms/Alias

 Gdi3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	IMSVNGKKVLHMDQN	ubiquitination	[1]
54	TPLEDLYKRFKLPGQ	ubiquitination	[1]
57	EDLYKRFKLPGQPPA	acetylation	[2]
57	EDLYKRFKLPGQPPA	succinylation	[2]
57	EDLYKRFKLPGQPPA	ubiquitination	[1]
112	IEGSFVYKGGKIYKV	acetylation	[3, 4]
112	IEGSFVYKGGKIYKV	ubiquitination	[1]
142	FEKRRFRKFLVYVAN	ubiquitination	[1]
153	YVANFDEKDPRTFEG	ubiquitination	[1]
164	TFEGVDPKKTSMRDV	acetylation	[2]
164	TFEGVDPKKTSMRDV	ubiquitination	[1]
174	SMRDVYKKFDLGQDV	acetylation	[3]
174	SMRDVYKKFDLGQDV	ubiquitination	[1]
269	NGKVVGVKSEGEIAR	acetylation	[2, 3]
269	NGKVVGVKSEGEIAR	succinylation	[2]
269	NGKVVGVKSEGEIAR	ubiquitination	[1]
278	EGEIARCKQLICDPS	ubiquitination	[1]
288	ICDPSYVKDRVEKVG	acetylation	[3]
293	YVKDRVEKVGQVIRV	acetylation	[3]
293	YVKDRVEKVGQVIRV	ubiquitination	[1]
309	CILSHPIKNTNDANS	acetylation	[3]
329	PQNQVNRKSDIYVCM	acetylation	[3]
360	VSTTVETKEPEKEIR	ubiquitination	[1]
418	ETTCDDIKDIYKRMT	acetylation	[3]
418	ETTCDDIKDIYKRMT	ubiquitination	[1]
422	DDIKDIYKRMTGSEF	acetylation	[2, 3]
435	EFDFEEMKRKKNDIY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 112 112 N6-acetyllysine (By similarity).
 MOD_RES 269 269 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; GTPase activation; Membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IPI:MGI.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005093; F:Rab GDP-dissociation inhibitor activity; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IPI:MGI.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IPI:MGI. 

Interpro

 IPR018203; GDP_dissociation_inhibitor.
 IPR000806; RabGDI. 

Pfam

 PF00996; GDI 

SMART

  

PROSITE

  

PRINTS

 PR00892; RABGDI.
 PR00891; RABGDIREP.