CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ryanodine receptor 2 
Protein Synonyms/Alias
  
Gene Name
 RYR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2120LLSVRMGKEEEKLMImethylation[1]
2124RMGKEEEKLMIRGLGmethylation[1]
2196RISRQNQKAMFDHLSubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4951 AA 
Protein Sequence
DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT FVLEQSLSVR 60
ALQEMLANTV EKSEGQVDVE KWKFMMKTAQ GGGHRTLLYG HAILLRHSYS GMYLCCLSTS 120
RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV SSERYLHLSY 180
GNGSLHVDAA FQQTLWSVAP ISSGSEAAQG YLIGGDVLRL LHGHMDECLT VPSGEHGEEQ 240
RRTVHYEGGA VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL SLMEDKNLLL 300
MDKEKADVKS TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV DTGLWLTYQS 360
VDVKSVRMGS IQRKAIMHHE GHMDDGISLS RSQHEESRTA RVIRSTVFLF NRFIRGLDAL 420
SKKAKASTVD LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ NRLRALKNRQ NLFQEEGMIN 480
LVLECIDRLH VYSSAAHFAD VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD 540
WLISRLERLE ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS 600
LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG SAQYKKWYYE 660
LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG FDGLHLWSGC 720
IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG LFFPVVSFSA 780
GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS 840
LTQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP 900
CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGISDEH AEDKVKKMKL PKNYQLTSGY 960
KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW TYGIQQDVKN RRNPRLVPYT 1020
LLDDRTKKSN KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR IFRAEKTYAV 1080
KAGRWYFEFE TVTAGDMRVG WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH QGNEHYGRSW 1140
QAGDVVGCMV DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGFIPVCS LGVAQVGRMN 1200
FGKDVSTLKY FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE HIEVTRIDGT 1260
IDSSPCLKVT QKSFGSQNSN TDIMFYRLSM PIECAEVFSK TVAGGLPGAG LFGPKNDLED 1320
YDADSDFEVL MKTAHGHLVP DRVDKDKEAT KPEFNNHKDY AQEKPSRLKQ RFLLRRTKPD 1380
YSTSHSARLT EDVLADDRDD YDFLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG 1440
FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG 1500
LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL SAGLFKSEHK 1560
NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ FMSLHIPEEN 1620
RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL YAIENKYMPG 1680
LLRAGYYDLL IDIHLSSYAT ARLMMNNEYI VPMTEETKSI TLFPDENKKH GLPGIGLSTS 1740
LRPRMQFSSP SFVSISNECY QYSPEFPLDI LKSKTIQMLT EAVKEGSLHA RDPVGGTTEF 1800
LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK ELSVDDAKLQ 1860
GAGEEEAKGG KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV AFSDDFVAKL 1920
QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC PCPEEIRDQL 1980
LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK PVESDSKKSS 2040
TLQQLISETM VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY TINGVSVEDT 2100
INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG MHETVMEVMV 2160
NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS VGLASPAMRG 2220
STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS CQMLVSKGYP DIGWNPVEGE 2280
RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA MEEAIKIAED 2340
PSRDGPSPNS GSSKTLDTEE EEDDTIHMGN AIMTFYSALI DLLGRCAPEM HLIHAGKGEA 2400
IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA AMVLFLDRVY 2460
GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP LLTRCAPLFA 2520
GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ HLLRRLVFDV 2580
PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW GIFDALSQKK 2640
YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV DTSNITIPEK 2700
LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK EKEIYRWPIK 2760
ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI DMSNVTLSRD 2820
LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR EKAQDILKFL 2880
QINGYAVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG SRGKGEHFPY 2940
EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS LFCKLGVLVR 3000
HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE DLEKTMENLK 3060
QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV QVSCYRILTS 3120
LYALGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETHLD KHNIYSIYNT KSSRERAALS 3180
LPTNVEDVCP NIPSLEKLME EIVELAESGI RYTQMPHVME VILPMLCSYM SRWWEHGPEN 3240
NPERAEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI INKVKPQLLK 3300
THFLPLMEKL KKKAATVVSE EDHLKAEARG DMSEAELLIL DEFTTLARDL YAFYPLLIRF 3360
VDYNRAKWLK EPNPEAEELF RMVAEVFIYW SKSHNFKREE QNFVVQNEIN NMSFLITDTK 3420
SKMSKAAVSD QERKKMKRKG DRYSMQTSLI VAALKRLLPI GLNICAPGDQ ELIALAKNRF 3480
SLKDTEDEVR DIIRSNIHLQ GKLEDPAIRW QMALYKDLPN RTDDTSDPEK TVERVLDIAN 3540
VLFHLEQKSK RVGRRHYCLV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA 3600
VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ LILLFSRTAL 3660
TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE KEMEKQKLLY QQARLHDRGA 3720
AEMVLQTISA SKGETGPMVA ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL 3780
MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN 3840
YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV 3900
FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE LLKELMDLQK 3960
DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF FDMFLKLKDL TSSDTFKEYD 4020
PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE TLDYEEFVKR FHEPAKDIGF 4080
NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS 4140
RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA 4200
NKEESEKERP EEQGPRMAFF SILTVRSALF ALRYNILTLM RMLSLKSLKK QMKKVKKMTV 4260
KDMVTAFFSS YWSIFMTLLH FVASVFRGFF RIICSLLLGG SLVEGAKKIK VAELLANMPD 4320
PTQDEVRGDG EEGERKPLEA ALPSEDLTDL KELTEESDLL SDIFGLDLKR EGGQYKLIPH 4380
NPNAGLSDLM SNPVPMPEVQ EKFQEQKAKE EEKEEKEETK SEPEKAEGED GEKEEKAKED 4440
KGKQKLRQLH THRYGEPEVP ESAFWKKIIA YQQKLLNYFA RNFYNMRMLA LFVAFAINFI 4500
LLFYKVSTSS VVEGKELPTR SSSENAKVTS LDSSSHRIIA VHYVLEESSG YMEPTLRILA 4560
ILHTVISFFC IIGYYCLKVP LVIFKREKEV ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN 4620
TQSFPNNYWD KFVKRKVMDK YGEFYGRDRI SELLGMDKAA LDFSDAREKK KPKKDSSLSA 4680
VLNSIDVKYQ MWKLGVVFTD NSFLYLAWYM TMSVLGHYNN FFFAAHLLDI AMGFKTLRTI 4740
LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDGDTPDMKC DDMLTCYMFH 4800
MYVGVRAGGG IGDEIEDPAG DEYEIYRIIF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ 4860
QEQVKEDMET KCFICGIGND YFDTVPHGFE THTLQEHNLA NYLFFLMYLI NKDETEHTGQ 4920
ESYVWKMYQE RCWEFFPAGD CFRKQYEDQL N 4951 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0003300; P:cardiac muscle hypertrophy; IEA:Compara.
 GO:0071313; P:cellular response to caffeine; IEA:Compara.
 GO:0003143; P:embryonic heart tube morphogenesis; IEA:Compara.
 GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0010460; P:positive regulation of heart rate; IEA:Compara.
 GO:0086094; P:positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction; IEA:Compara.
 GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Compara.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Compara.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IEA:Compara.
 GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR000699; Ca-rel_channel.
 IPR008985; ConA-like_lec_gl_sf.
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR014821; Ins145_P3_rcpt.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR013333; Ryan_recept.
 IPR003032; Ryanodine_rcpt.
 IPR015925; Ryanodine_recept-rel.
 IPR009460; Ryanrecept_TM4-6.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF06459; RR_TM4-6
 PF01365; RYDR_ITPR
 PF02026; RyR
 PF00622; SPRY 
SMART
 SM00054; EFh
 SM00472; MIR
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50222; EF_HAND_2
 PS50919; MIR 
PRINTS
 PR00795; RYANODINER.