UniProt Accession

 ERCC3_MOUSE; P49135 

Genbank Protein ID

 S71186; BC016595; BC026575 

Genbank Nucleotide ID

 AAB20614.1; AAH16595.1; AAH26575.1 

Protein Name

 TFIIH basal transcription factor complex helicase XPB subunit 

Protein Synonyms/Alias

 Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH 89 kDa subunit; Xeroderma pigmentosum group B-complementing protein 

Gene Name

 Ercc3 

Gene Synonyms/Alias

 Xpb; Xpbc 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
602	QNFKHNPKINTIFIS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage. 

Sequence Annotation

 DOMAIN 328 489 Helicase ATP-binding.
 DOMAIN 543 703 Helicase C-terminal.
 NP_BIND 341 348 ATP (By similarity).
 MOTIF 6 18 Nuclear localization signal (Potential).
 MOTIF 442 445 DEVH box.  

Keyword

 ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 783 AA 

Protein Sequence

Gene Ontology

 GO:0005675; C:holo TFIIH complex; ISS:UniProtKB.
 GO:0000441; C:SSL2-core TFIIH complex; IEA:Compara.
 GO:0043138; F:3'-5' DNA helicase activity; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:Compara.
 GO:0032564; F:dATP binding; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:Compara.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:Compara.
 GO:0000075; P:cell cycle checkpoint; IEA:Compara.
 GO:0006265; P:DNA topological change; ISS:UniProtKB.
 GO:0035315; P:hair cell differentiation; IEA:Compara.
 GO:0006917; P:induction of apoptosis; ISS:UniProtKB.
 GO:0000717; P:nucleotide-excision repair, DNA duplex unwinding; IEA:Compara.
 GO:0033683; P:nucleotide-excision repair, DNA incision; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; ISS:UniProtKB.
 GO:0009650; P:UV protection; IGI:MGI. 

Interpro

 IPR006935; Helicase/UvrB_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR001161; Helicase_Ercc3.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00271; Helicase_C
 PF04851; ResIII 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 

PRINTS

 PR00851; XRODRMPGMNTB.