UniProt Accession

 AOFB_HUMAN; P27338; B2R6R3; D3DWC3; Q7Z6S2 

Genbank Protein ID

 S62734; M69135; AK312679; M69177; M89637; AL008709; AL020990; Z95125; CH471141; CH471141 

Genbank Nucleotide ID

 AAB27229.1; AAA59551.1; BAG35560.1; AAA59550.1; AAB46386.1; EAW59378.1; EAW59380.1 

Protein Name

 Amine oxidase [flavin-containing] B 

Protein Synonyms/Alias

 Monoamine oxidase type B; MAO-B 

Gene Name

 MAOB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	TLRNQKVKYVDLGGS	ubiquitination	[1, 2]
73	NRILRLAKELGLETY	ubiquitination	[1, 2]
81	ELGLETYKVNEVERL	ubiquitination	[1, 2]
136	IPSDAPWKAPLAEEW	ubiquitination	[1, 2]
209	TNGGQERKFVGGSGQ	ubiquitination	[1]
230	DLLGDRVKLERPVIY	ubiquitination	[1]
456	EILHAMGKIPEDEIW	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 52 52 N6-acetyllysine (By similarity).
 MOD_RES 397 397 S-8alpha-FAD cysteine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 520 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara.
 GO:0008131; F:primary amine oxidase activity; TAS:Reactome.
 GO:0014063; P:negative regulation of serotonin secretion; IEA:Compara.
 GO:0045964; P:positive regulation of dopamine metabolic process; IEA:Compara.
 GO:0010044; P:response to aluminum ion; IEA:Compara.
 GO:0051412; P:response to corticosterone stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0010269; P:response to selenium ion; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR002937; Amino_oxidase.
 IPR001613; Flavin_amine_oxidase. 

Pfam

 PF01593; Amino_oxidase 

SMART

  

PROSITE

  

PRINTS

 PR00757; AMINEOXDASEF.