| Tag | Content |
|---|
| CPLM ID | CPLM-022141 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ethylmalonyl-CoA decarboxylase |
Protein Synonyms/Alias | Enoyl-CoA hydratase domain-containing protein 1; Methylmalonyl-CoA decarboxylase; MMCD |
Gene Name | ECHDC1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | GGSIDLQKEDNGIGI | ubiquitination | [1] | | 94 | LENWTEGKGLIVRGA | ubiquitination | [1] | | 102 | GLIVRGAKNTFSSGS | ubiquitination | [1] | | 215 | GALKLDSKNALNIGM | ubiquitination | [1] | | 244 | EEAQEWLKQFIQGPP | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activityx at lower level. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Lyase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 307 AA |
Protein Sequence | MAKSLLKTAS LSGRTKLLHQ TGLSLYSTSH GFYEEEVKKT LQQFPGGSID LQKEDNGIGI 60
LTLNNPSRMN AFSGVMMLQL LEKVIELENW TEGKGLIVRG AKNTFSSGSD LNAVKSLGTP 120
EDGMAVCMFM QNTLTRFMRL PLISVALVQG WALGGGAEFT TACDFRLMTP ESKIRFVHKE 180
MGIIPSWGGT TRLVEIIGSR QALKVLSGAL KLDSKNALNI GMVEEVLQSS DETKSLEEAQ 240
EWLKQFIQGP PEVIRALKKS VCSGRELYLE EALQNERDLL GTVWGGPANL EAIAKKGKFN 300
K 301 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0016831; F:carboxy-lyase activity; ISS:UniProtKB. GO:0004492; F:methylmalonyl-CoA decarboxylase activity; IEA:EC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |