UniProt Accession

 BAD_HUMAN; Q92934; O14803; Q6FH21 

Genbank Protein ID

 U66879; AF021792; AF031523; AK291863; BT006678; CR541935; CR541959; AB451254; AB451378; CH471076; BC001901; BC095431 

Genbank Nucleotide ID

 AAB36516.1; AAB72092.1; AAB88124.1; BAF84552.1; AAP35324.1; CAG46733.1; CAG46757.1; BAG70068.1; BAG70192.1; EAW74235.1; AAH01901.1; AAH95431.1 

Protein Name

 Bcl2 antagonist of cell death 

Protein Synonyms/Alias

 BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter 

Gene Name

 BAD 

Gene Synonyms/Alias

 BBC6; BCL2L8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	DGPSGSGKHHRQAPG	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. 

Sequence Annotation

 MOTIF 110 124 BH3.
 MOD_RES 75 75 Phosphoserine; by PKA, PKB, PIM2, PIM3,
 MOD_RES 91 91 Phosphoserine.
 MOD_RES 94 94 Asymmetric dimethylarginine; by PRMT1.
 MOD_RES 96 96 Asymmetric dimethylarginine; by PRMT1.
 MOD_RES 99 99 Phosphoserine; by PKA, PKB, PAK1,
 MOD_RES 99 99 Phosphoserine; by PKB/AKT1; alternate.
 MOD_RES 118 118 Phosphoserine.
 MOD_RES 134 134 Phosphoserine (By similarity).  

Keyword

 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Membrane; Methylation; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IDA:UniProtKB.
 GO:0005543; F:phospholipid binding; IMP:UniProtKB.
 GO:0046031; P:ADP metabolic process; ISS:UniProtKB.
 GO:0046034; P:ATP metabolic process; ISS:UniProtKB.
 GO:0060154; P:cellular process regulating host cell cycle in response to virus; IEA:Compara.
 GO:0071247; P:cellular response to chromate; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEP:UniProtKB.
 GO:0071396; P:cellular response to lipid; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
 GO:0071316; P:cellular response to nicotine; IDA:UniProtKB.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0006007; P:glucose catabolic process; IEA:Compara.
 GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
 GO:0006917; P:induction of apoptosis; IDA:UniProtKB.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
 GO:0046931; P:pore complex assembly; IDA:UniProtKB.
 GO:0010508; P:positive regulation of autophagy; TAS:UniProtKB.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:UniProtKB.
 GO:0033133; P:positive regulation of glucokinase activity; ISS:UniProtKB.
 GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.
 GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; TAS:Reactome.
 GO:0010918; P:positive regulation of mitochondrial membrane potential; ISS:UniProtKB.
 GO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome.
 GO:0045862; P:positive regulation of proteolysis; IDA:BHF-UCL.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
 GO:0045582; P:positive regulation of T cell differentiation; IEA:Compara.
 GO:2000078; P:positive regulation of type B pancreatic cell development; ISS:UniProtKB.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IMP:UniProtKB.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0034201; P:response to oleic acid; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara.
 GO:0044342; P:type B pancreatic cell proliferation; ISS:UniProtKB. 

Interpro

 IPR018868; Bcl-2_BAD. 

Pfam

 PF10514; Bcl-2_BAD 

SMART

  

PROSITE

 PS01259; BH3 

PRINTS