CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024184
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptopodin 
Protein Synonyms/Alias
  
Gene Name
 Synpo 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
392SSILLIDKVSAPPSAubiquitination[1]
464EVHLTLAKPASVVNRubiquitination[1]
501GRRHFGEKAWAPPASubiquitination[1]
583LYPSSDPKPPHLKGQubiquitination[1]
596GQVVPANKTGILEESubiquitination[1]
611MARRGSRKSMFTFVEacetylation[2]
619SMFTFVEKPKVTPNPacetylation[2]
638LVQTADEKRRQRDQGubiquitination[1]
726RRQSRMEKYVIESSGubiquitination[1]
838PRAASPAKPSSLDLVubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. 
Sequence Annotation
 MOTIF 551 554 PPxY motif.
 MOTIF 570 573 PPxY motif.
 MOD_RES 258 258 Phosphoserine (By similarity).
 MOD_RES 490 490 Phosphoserine (By similarity).
 MOD_RES 514 514 Phosphoserine (By similarity).
 MOD_RES 537 537 Phosphoserine (By similarity).
 MOD_RES 569 569 Phosphoserine (By similarity).
 MOD_RES 691 691 Phosphoserine (By similarity).
 MOD_RES 742 742 Phosphoserine (By similarity).
 MOD_RES 835 835 Phosphoserine (By similarity).
 MOD_RES 884 884 Phosphoserine (By similarity).
 MOD_RES 886 886 Phosphothreonine (By similarity).  
Keyword
 Actin-binding; Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 931 AA 
Protein Sequence
MLGTHFPPPP LGPSEGRAAP CTFQIPDGSY RCLALEAEES SSEDGLQGEV RLVDLEEEGT 60
SKSRVNHGTP PLSRAPAIIQ PSSCCREARG GFQHSDKPSR EWDVVQARKV MTASVSSSPV 120
PRVAQKPALG RSTSFTEKDL KEAKERSQRI AAQLTTPPSS NSRGVQLFNR RRQRVNEFTL 180
ESRGQRSPKL SQEALQTGHP SSPIGHAPGL SVNPTSPSKP GSPKHSSSQS PSRGVPGHIM 240
EGYSEEASLL RHLEKVASEE EEVPLVVYLK ENAALLTANG LHLSQNRETQ QSSPNPPETE 300
EVPSPAADIN QNPSSPNATL TTAASNSHHN QPTADVNQNP PATITPVQQN SSETQCSPNG 360
TLDSKPNTPS ADDGQRPVPA EEVRSSILLI DKVSAPPSAA SPFSREATPL SSSGPPAADL 420
MSSSLLIGMQ PSTLVASAEQ EVSGHAAVTT PTKVYSEVHL TLAKPASVVN RTARPFGMQS 480
PGTTSQIEQS PMMGRRHFGE KAWAPPASSM ADRSPQPQRH IMARSPMVER RLVGQRSPVV 540
ERRPLGNFTP PPTYAETLST APVASQVRSP PSYSTLYPSS DPKPPHLKGQ VVPANKTGIL 600
EESMARRGSR KSMFTFVEKP KVTPNPDLLD LVQTADEKRR QRDQGEVGME DEPFALGAEA 660
SNFQQEPIAR DRSGPAAAEE TVPEWASCLK SPRIQAKPKP KPNQNLSEAS GKGAELYARR 720
QSRMEKYVIE SSGHAELARC PSPTMSLPSS WKYTTNAPGG FRVASLSPAR TPPASLYHGY 780
LPENGVLRPE PTKQQPHQMR PSLYALSPVK EPAKISSRAT SSRASSRTVS PRAASPAKPS 840
SLDLVPNLPR AGLPPSPALP RPSRSSPGLY NAPVQDSLQP TAVSPTYSSD ISPVSPSRAW 900
SPRAKQAPRP SFSTRNAGIE AQVWKPSFCF K 931 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0032233; P:positive regulation of actin filament bundle assembly; IEA:Compara.
 GO:0051492; P:regulation of stress fiber assembly; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS