CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative RNA-binding protein 15 
Protein Synonyms/Alias
 One-twenty two protein 1; RNA-binding motif protein 15 
Gene Name
 RBM15 
Gene Synonyms/Alias
 OTT; OTT1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
406VITEVDIKRPSRGQTubiquitination[1]
450PIKIGYGKATPTTRLacetylation[2]
850DEVTRRIKVAGPNGYubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 May be implicated in HOX gene regulation. 
Sequence Annotation
 DOMAIN 170 252 RRM 1.
 DOMAIN 374 451 RRM 2.
 DOMAIN 455 529 RRM 3.
 DOMAIN 777 956 SPOC.
 MOD_RES 109 109 Phosphoserine.
 MOD_RES 210 210 Phosphoserine.
 MOD_RES 257 257 Phosphoserine.
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 292 292 Phosphoserine.
 MOD_RES 294 294 Phosphoserine.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 450 450 N6-acetyllysine.
 MOD_RES 568 568 Phosphothreonine.
 MOD_RES 622 622 Phosphoserine.
 MOD_RES 670 670 Phosphoserine.
 MOD_RES 674 674 Phosphoserine.
 MOD_RES 700 700 Phosphoserine.
 MOD_RES 741 741 Phosphoserine.
 MOD_RES 765 765 Phosphoserine.
 MOD_RES 935 935 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Host-virus interaction; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 977 AA 
Protein Sequence
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER SPVKAKRSRG 60
GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL DKSSSRGGSR EYDTGGGSSS 120
SRLHSYSSPS TKNSSGGGES RSSSRGGGGE SRSSGAASSA PGGGDGAEYK TLKISELGSQ 180
LSDEAVEDGL FHEFKRFGDV SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL 240
YDRPLKIEAV YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL 300
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG AGAGAAPFRE 360
VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI TEVDIKRPSR GQTSTYGFLK 420
FENLDMSHRA KLAMSGKIII RNPIKIGYGK ATPTTRLWVG GLGPWVPLAA LAREFDRFGT 480
IRTIDYRKGD SWAYIQYESL DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP 540
LPLTHYELVT DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT 600
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG RHLDRSPESD 660
RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS PIRDRRGSLE KSQGDKRDRK 720
NSASAERDRK HRTTAPTEGK SPLKKEDRSD GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA 780
SPKLCLAWQG MLLLKNSNFP SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP 840
KLDEVTRRIK VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA 900
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM IIVRGFGFQI 960
GVRYENKKRE NLALTLL 977 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0045638; P:negative regulation of myeloid cell differentiation; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0060674; P:placenta blood vessel development; IEA:Compara.
 GO:0007221; P:positive regulation of transcription of Notch receptor target; IEA:Compara.
 GO:0048536; P:spleen development; IEA:Compara.
 GO:0060412; P:ventricular septum morphogenesis; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR012921; SPOC_C.
 IPR016194; SPOC_like_C_dom.
 IPR010912; SPOC_met. 
Pfam
 PF00076; RRM_1
 PF07744; SPOC 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM
 PS50917; SPOC 
PRINTS