CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039091
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Afadin 
Protein Synonyms/Alias
  
Gene Name
 Mllt4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
303FREWPSDKGILVFQLacetylation[1]
329MKKHVEGKPLKGKDRacetylation[1]
1213YFTFPASKSQDRMAPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1781 AA 
Protein Sequence
DLEFHGVMRF YFQDKAAGNF ATKCIRVSST ATTQDVIETL AEKFRPDMRM LSSPKYSLYE 60
VHVSGEERRL DIDEKPLVVQ LNWNKDDREG RFVLKNENDA IPAKKAQSNG PEKQEKEGVI 120
QNFKRTLSKK EKKEKKKREK EALRQASDKE ERPSQGDDRA NLSQLLVTGG TVTETVMSAL 180
LWKPEALQGN WRACIMENRL RESNQHDGQF SSGGTLRIYA DSLKPNIPYK TILLSTTDPA 240
DFAVAESLEK YGEKENPKDY CIARVRLILS LSLSLSDERG AKEIILDDDE CPLQIFREWP 300
SDKGILVFQL KRRPPDYIPK KMKKHVEGKP LKGKDRADGS GYGSALPPEK LPYLVELSPG 360
RRNHFAYYSY HTYEDGSDSR DKPKLYRLQL SVTEVGTEKF DDNSIQLFGP GIQPHHCDLT 420
NMDGVVTVTP RSMDAETYVD GQRISETTML QSGMRLQFGT SHVFKFVDPI QDHVLSKRSV 480
DGGLMVKGPR HKPGAVQETT FELGGDIHSG TALPASRSTT RLDSDRVSSA SSTAERGMVK 540
PMIRLDQEQD YRRRESRTQD AAGPELMLPA SIEFRESSED SFLSAIINYT NSSTVHFKLS 600
PTYVLYMACR YVLSSQHRPD ISPTERTHKA IAVVNKMVSM MEGVIQEVDQ VDQKQKNIAG 660
ALAFWMANAS ELLNFIKQDR DLSRITLDAQ DVLAHLVQMA FKYLVHCLQS ELNNYMPAFL 720
DDPEENSLQR PKIDDVLHTL TGAMSLLRRC RVNAALTIQL FSQLFHFINM WLFNRLVTDP 780
DSGLCSHYWG AIIRQQLGHI EAWAEKQGLE LAADCHLSRI VQATTLLTMD KYVPDDIPNI 840
NSTCFKLNSL QLQALLQNYH CAPDEPFIPT DLIENVVAVA ENTADELARS DGRDVQLEED 900
PDLQLPFLLP EDGYSCDVVR NIPNGLQEFL DPLCQRGFCR LVPHTRSPGT WTIYFEGADY 960
ESHLMRENTE LTQPLRKEPE VITVTLKKQN GMGLSIVAAK GAGQDKLGIY VKSVVKGGAA 1020
DVDGRLAAGD QLLSVDGRSL VGLSQERAAE LMTRTSSVVT LEVAKQGAIY HGLATLLNQP 1080
SPMMQRMSEI AVSGVLKPSS KFFERGTNSP HGVAPTTGLA QLFKEEYCEP SSDPASALLF 1140
TNSSDHRSSP NVANQPPSPG GKSPYTSGTA AKITSVSTGN LCTEEQTPPP RPEAYPIPTQ 1200
TYTREYFTFP ASKSQDRMAP VQNQWPNYEE KPHMHTESDH ASIAIQRVTR SQEELREEKV 1260
YQLERHRVES GMDRKCDSDM WINQSSSVES STSSQEHLNH SSKSVTPAST LTKSGPGRWK 1320
TPAAVLPTPV AVSQPIRTDL PPPPPPPPAH YTSDFDGISM DLPLPPPPAN QAAPQSAQVA 1380
AAERKKREEH QRWYEKEKAR LEEERERKRR EQERKLGQMR TQSLNPASFS PLATQAKPEK 1440
PSTLQRPQET VIRELQPQQQ PRTIERRDLQ YITISKEELS SGDSLSPDPW KRDAREKLEK 1500
QQQMHIVDML SKEIHELQNK GDRTAEESDR LRKLMLEWQF QKRLQESKQK DEDDDEEEDD 1560
DVDTMLIMQR LEAERRARLQ DEERRRQQQL EEMRKREVED RVRQEEDGRH QEEERVKRDA 1620
EEKRRQEEGY YSRLEAERRR QHEEAARRLL EPEEPGLSRP PLPQDYEPPS QSSAPSAPPP 1680
PPQRNASYLK TQVLSPDSLF TAKFVAYDDD DEEENYVPAG PNSYSGSAGT TAGTYDAPRD 1740
TREKLSRSQD ADLPGSSGAP ENLTFRERQR LFSQGQTPSE K 1781 
Gene Ontology
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR018444; Dil_domain.
 IPR002710; Dilute.
 IPR000253; FHA_dom.
 IPR001478; PDZ.
 IPR000159; Ras-assoc.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF01843; DIL
 PF00498; FHA
 PF00595; PDZ
 PF00788; RA 
SMART
 SM00240; FHA
 SM00228; PDZ
 SM00314; RA 
PROSITE
 PS51126; DILUTE
 PS50106; PDZ
 PS50200; RA 
PRINTS