CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038326
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Unconventional myosin-VI 
Protein Synonyms/Alias
  
Gene Name
 Myo6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
334IGLDDEEKLDLFRVVacetylation[1]
1066GPAVQATKAAAGTKKubiquitination[2]
1131ETEQRAPKSVTDYDFubiquitination[2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1284 AA 
Protein Sequence
MEDGKPVWAP HPTDGFQMGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP AEEDSKKDVE 60
DNCSLMYLNE ATLLHNVKVR YSKDRIYTYV ANILIAVNPY FDIPKIYSSD TIKSYQGKSL 120
GTMPPHVFAI ADKAFRDMKV LKMSQSIIVS GESGAGKTEN TKFVLRYLTE SYGTGQDIDD 180
RIVEANPLLE AFGNAKTVRN NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK 240
EERNYHIFYR LCAGASEDIR EKLHLSSPDN FRYLNRGCTR FFANKETDKQ ILQNRKSPEY 300
VKAGSLKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI DFEEAGSTSG 360
GCNLKNKSAP SLEYCAELLG LDQDDLRVSL TTRVMLTTAG GTKGTVIKVP LKVEQANNAR 420
DALAKTVYSH LFDHVVNRVN QCFPFETSSY FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL 480
QQFFNERILK EEQELYQKEG LGVNEVHYVD NQDCIDLIEV KLVGILDILD EENRLPQPSD 540
QHFTSVVHQK HKDHFRLTIP RKSKLAVHRN LRDDEGFIIR HFAGAVCYET TQFVEKNNDA 600
LHMSLESLIC ESRDKFIRAL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ LNLLLDKLRS 660
TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL MQGGFPSRAS FHELYNMYKK 720
YMPEKLARLD PRLFCKALFK ALGLNEVDYK FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL 780
VKRVNLWLVC SRWKKVQWCS LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL 840
VKVGTLKKRL DKFNEVVSAL KDGKPEVNRQ IKNLEISIDA LMAKIKSTMM TREQIQKEYD 900
ALVKSSEDLL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEERRRKE EEERRMKLEM 960
EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQREEESQQQ AVLAQECRDR ELALRIAQNE 1020
SELISDEAQG DMALRSLSSC PATSKEQMAK EMSEILSRGP AVQATKAAAG TKKHDLSKWK 1080
YAELRDTINT SCDIELLAAC REEFHRRLKV YHAWKSKNKK RNTETEQRAP KSVTDYDFAP 1140
FLNNSPQQNP AAQLPARQQE IDMKRQQRFF RIPFIRPADQ YKDPQNKKKG WWYAHFDGPW 1200
IARQMELHPD KPPILLVAGK DDMEMCELNL EETGLTRKRG AEILPRQFEE IWERCGGIQY 1260
LQSAIESRQA RPTYATAMLQ NLLK 1284 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0005886; C:plasma membrane; IPI:MGI.
 GO:0045202; C:synapse; ISO:MGI.
 GO:0012506; C:vesicle membrane; IPI:MGI.
 GO:0051015; F:actin filament binding; ISO:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0042491; P:auditory receptor cell differentiation; IMP:MGI.
 GO:0071257; P:cellular response to electrical stimulus; IMP:MGI.
 GO:0016358; P:dendrite development; IMP:MGI.
 GO:0006897; P:endocytosis; IMP:MGI.
 GO:0014047; P:glutamate secretion; IMP:MGI.
 GO:0042472; P:inner ear morphogenesis; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0006605; P:protein targeting; IPI:MGI.
 GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0007416; P:synapse assembly; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
  
PRINTS
 PR00193; MYOSINHEAVY.