CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006734
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol 4-kinase STT4 
Protein Synonyms/Alias
 PI4-kinase; PtdIns-4-kinase 
Gene Name
 STT4 
Gene Synonyms/Alias
 YLR305C; L2142.4 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
475QLTITSGKNIEKDYFubiquitination[1]
479TSGKNIEKDYFPLRNubiquitination[1]
1175MEYSPYDKAGINRDAubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway. 
Sequence Annotation
 DOMAIN 1345 1530 PIK helical.
 DOMAIN 1643 1882 PI3K/PI4K.
 REGION 1531 1648 Pleckstrin homology (PH) domain
 MOD_RES 459 459 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1900 AA 
Protein Sequence
MRFTRGLKAS SSLRAKAIGR LTKLSTGAPN DQNSNGTTLD LITHTLPIFY STNTSKIYTI 60
PLTLSEWEVL TSLCVAIPTT LDLVETMLKE IIAPYFLETP RQRISDVLSS KFKLEQMRNP 120
IELLTFQLTK FMIQACEQYP VLYENIGGII STYFERVLKI FTIKQSGLLS LVGFINAFIQ 180
FPNSTELTKF TWKKLAKLVL RGSFLNEVDK ILNSSATFTN DSIVQYYDAG NELSSAYLLE 240
LISRLQVSLI SHLLNTSHVG ANLSEFLLNQ QYQFYKFDQE VADENDDTKC IDDFFFNVRS 300
NKQFFTDMCK ISLQFCSESH ILDLSTDNRA RFSFDTRAHY LQTLCLIPFI EDTESELFES 360
FTNVVSESID KFFLSDVVTP SLIKAIVASA SLLNFFTEKL SLTLIRMFPL LVASPHITTE 420
TVNDVAKIFT TGLYPLNEDA IVSTIYSMNN LLAVSEDGSP VPVLRERQLT ITSGKNIEKD 480
YFPLRNSSAS LDGTGALLGN TTVGQLSSHD VNSGATMTYH ASLISNCVAA TTTIASYYNT 540
QSITALTISI LTQKVNSMSK ELDGVILNSL ARLAPNTSLT EFSLLLKFFK SRTVIATKID 600
DSALLKNIIK AKCVISKELL ARHFSSDLYF MYLHDLLDSI IASGEVERLE HHRPQTEISR 660
VADQIATYLE PLAALLPVPG DTPLDINKDE VTTNKFRNAW FNFVIHGYHL GGPIVKRNFS 720
FLLTIAYNSP PLASEFPANN KELSLEMNTI LRRGSSNENI KQQKQQITEY FNTNIVQYRT 780
TSSSKIMFLA AAVLLETIRC EAGDCSKTLL YFSDPSILSG SIEKCIAVLS VSMIRKYARL 840
IQKGNDAIFN SKMIAQQLNN LLLCLSHREP TLQDAAFHAC EIFIRSIPSS LCHHLSLYTL 900
LDMLTALFDS ILDSEAHKFE PRYEFKLKHS KTTILVPSSS SWRATTLSRL HKSAKEWVRI 960
LLNRSNQDTK ILLQSYISDL GEYSRLNSVE FGVSFAMDMA GLILPADKEL SRLTYYGPEK 1020
PNTISGFISL HSWRSKYLFD TAITSSPEDI KRQIGISTQN IRKNLTLGNK IITKDVTDFL 1080
DMATALLILG NGAPASLIYD IVHIPFEVFT SASLKIATNV WLTIITEKPE VAHLLLVEVC 1140
YCWMRSIDDN IGLYSRDHDL KGEEYQKMEY SPYDKAGINR DAKNASQAMQ PHLHVIKFFA 1200
SHFEGTLFQS DFLLKIFTKC ALYGIKNLYK ASLHPFARMI RHELLLFATL VLNASYKQGS 1260
KYMGRLSQEI TNGALSWFKR PVAWPFGSNE LKIKADLSVT RDLFLQLNKL SSLMSRHCGK 1320
DYKILNYFLA SEIQQIQTWL TPTEKIEGAD SNELTSDIVE ATFAKDPTLA INLLQRCYSK 1380
KAEDVLVGLV AKHALMCVGS PSALDLFIKG SHLSSKKDLH ATLYWAPVSP LKSINLFLPE 1440
WQGNSFILQF SIYSLESQDV NLAFFYVPQI VQCLRYDKTG YVERLILDTA KISVLFSHQI 1500
IWNMLANCYK DDEGIQEDEI KPTLDRIRER MVSSFSQSHR DFYEREFEFF DEVTGISGKL 1560
KPYIKKSKAE KKHKIDEEMS KIEVKPDVYL PSNPDGVVID IDRKSGKPLQ SHAKAPFMAT 1620
FKIKKDVKDP LTGKNKEVEK WQAAIFKVGD DCRQDVLALQ LISLFRTIWS SIGLDVYVFP 1680
YRVTATAPGC GVIDVLPNSV SRDMLGREAV NGLYEYFTSK FGNESTIEFQ NARNNFVKSL 1740
AGYSVISYLL QFKDRHNGNI MYDDQGHCLH IDFGFIFDIV PGGIKFEAVP FKLTKEMVKV 1800
MGGSPQTPAY LDFEELCIKA YLAARPHVEA IIECVNPMLG SGLPCFKGHK TIRNLRARFQ 1860
PQKTDHEAAL YMKALIRKSY ESIFTKGYDE FQRLTNGIPY 1900 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00454; PI3_PI4_kinase
 PF00613; PI3Ka 
SMART
 SM00145; PI3Ka
 SM00146; PI3Kc 
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3
 PS51545; PIK_HELICAL 
PRINTS