UniProt Accession

 NEST_HUMAN; P48681; O00552; Q3LIF5; Q5SYZ6 

Genbank Protein ID

 AL590666; X65964; AF004335; AB073350 

Genbank Nucleotide ID

 CAI16338.1; CAA46780.1; AAB64426.1; BAE45713.1 

Protein Name

 Nestin 

Protein Synonyms/Alias

  

Gene Name

 NES 

Gene Synonyms/Alias

 Nbla00170 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
74	VDQRWREKHAAEVAR	ubiquitination	[1]
120	RRAVEAEKCARAWLS	ubiquitination	[1]
271	VEALEQEKQGLQSQI	ubiquitination	[1]
819	EESVEAVKSLETEIL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). 

Sequence Annotation

 REGION 1 7 Head.
 REGION 8 313 Rod.
 REGION 8 43 Coil 1A.
 REGION 44 55 Linker 1.
 REGION 56 151 Coil 1B.
 REGION 152 173 Linker 12.
 REGION 174 192 Coil 2A.
 REGION 193 195 Linker 2.
 REGION 196 313 Coil 2B.
 REGION 314 1621 Tail.
 MOD_RES 311 311 Phosphoserine.
 MOD_RES 315 315 Phosphothreonine.
 MOD_RES 325 325 Phosphoserine.
 MOD_RES 355 355 Phosphoserine.
 MOD_RES 358 358 Phosphoserine.
 MOD_RES 388 388 Phosphothreonine.
 MOD_RES 398 398 Phosphoserine.
 MOD_RES 471 471 Phosphoserine.
 MOD_RES 548 548 Phosphoserine.
 MOD_RES 564 564 Phosphoserine.
 MOD_RES 578 578 Phosphoserine.
 MOD_RES 588 588 Phosphoserine.
 MOD_RES 680 680 Phosphoserine.
 MOD_RES 746 746 Phosphoserine.
 MOD_RES 768 768 Phosphoserine.
 MOD_RES 790 790 Phosphoserine.
 MOD_RES 820 820 Phosphoserine.
 MOD_RES 831 831 Phosphoserine.
 MOD_RES 851 851 Phosphothreonine.
 MOD_RES 894 894 Phosphoserine.
 MOD_RES 905 905 Phosphoserine.
 MOD_RES 913 913 Phosphoserine.
 MOD_RES 934 934 Phosphoserine.
 MOD_RES 1261 1261 Phosphoserine.
 MOD_RES 1282 1282 Phosphoserine.
 MOD_RES 1286 1286 Phosphoserine.
 MOD_RES 1347 1347 Phosphoserine.
 MOD_RES 1409 1409 Phosphoserine.
 MOD_RES 1418 1418 Phosphoserine.
 MOD_RES 1452 1452 Phosphoserine.
 MOD_RES 1496 1496 Phosphoserine.
 MOD_RES 1498 1498 Phosphoserine.
 MOD_RES 1577 1577 Phosphoserine.
 MOD_RES 1617 1617 Phosphoserine.
 MOD_RES 1618 1618 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Developmental protein; Intermediate filament; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1621 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:DFLAT.
 GO:0005882; C:intermediate filament; NAS:UniProtKB.
 GO:0019215; F:intermediate filament binding; ISS:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0007420; P:brain development; ISS:UniProtKB.
 GO:0048858; P:cell projection morphogenesis; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; ISS:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:DFLAT.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0043086; P:negative regulation of catalytic activity; IDA:UniProtKB.
 GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
 GO:0030844; P:positive regulation of intermediate filament depolymerization; ISS:UniProtKB.
 GO:2000179; P:positive regulation of neural precursor cell proliferation; ISS:UniProtKB.
 GO:0072089; P:stem cell proliferation; IMP:DFLAT. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS