CPLM-007830

Genbank Nucleotide ID

60S ribosomal protein L27a

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
47	HHRINFDKYHPGYFG	acetylation	[1]
47	HHRINFDKYHPGYFG	ubiquitination	[2, 3, 4, 5]
55	YHPGYFGKVGMKHYH	acetylation	[1]
55	YHPGYFGKVGMKHYH	ubiquitination	[2, 3, 5]
77	CPTVNLDKLWTLVSE	ubiquitination	[4, 6]
92	QTRVNAAKNKTGAAP	ubiquitination	[2, 3, 5, 7]
94	RVNAAKNKTGAAPII	ubiquitination	[2, 3, 4, 5, 7, 8]
110	VVRSGYYKVLGKGKL	acetylation	[1]
110	VVRSGYYKVLGKGKL	ubiquitination	[4]
114	GYYKVLGKGKLPKQP	ubiquitination	[4]
116	YKVLGKGKLPKQPVI	ubiquitination	[4]
125	PKQPVIVKAKFFSRR	ubiquitination	[4, 7]

[1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[8] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]

Functional Description

MOD_RES 39 39 (3S)-3-hydroxyhistidine.
MOD_RES 47 47 N6-acetyllysine.
MOD_RES 55 55 N6-acetyllysine.
MOD_RES 68 68 Phosphoserine.
MOD_RES 110 110 N6-acetyllysine.

3D-structure; Acetylation; Complete proteome; Hydroxylation; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
GO:0003723; F:RNA binding; TAS:ProtInc.
GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
GO:0006414; P:translational elongation; TAS:Reactome.
GO:0006413; P:translational initiation; TAS:Reactome.
GO:0006415; P:translational termination; TAS:Reactome.
GO:0019083; P:viral transcription; TAS:Reactome.

IPR001196; Ribosomal_L15_CS.
IPR021131; Ribosomal_L18e/L15P.

PF00828; Ribosomal_L18e

PS00475; RIBOSOMAL_L15