CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030464
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PHD finger protein 3 
Protein Synonyms/Alias
 cDNA FLJ31116 fis, clone IMR322000604, highly similar to PHD finger protein 3 
Gene Name
 PHF3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
143EEVCMSLKPEYHKENacetylation[1]
466PKKIVAAKYEVIHSKacetylation[2]
519QSCNSGVKSVKNQAHacetylation[3]
543QTLVQIFKPLTHSLSacetylation[1, 2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 822 AA 
Protein Sequence
MLSDKDPMLG SASNQFCLPV LDSNDPNFQM PCSTVVGLDD IMDEGVVKES GNDTIDEEEL 60
ILPNRNLRDK VEENSVRSPR KSPRLMAQEQ VRSLRQSTIA KRSNAAPLSN TKKASGKTVS 120
TAKAGVKQPE RSQVKEEVCM SLKPEYHKEN RRCSRNSGQI EVVPEVSVSS SHSSVSSCLE 180
MKDEDGLDSK HKCNNPGEID VPSHELNCSL LSETCVTIGE KKNEALMECK AKPVGSPLFK 240
FSDKEEHEQN DSISGKTGET VVEEMIATRK VEQDSKETVK LSHEDDHILE DAGSSDISSD 300
AACTNPNKTE NSLVGLPSCV DEVTECNLEL KDTMGIADKT ENTLERNKIE PLGYCEDAES 360
NRQLESTEFN KSNLEVVDTS TFGPESNILE NAICDVPDQN SKQLNAIEST KIESHETANL 420
QDDRNSQSSS VSYLESKSVK SKHTKPVIHS KQNMTTDAPK KIVAAKYEVI HSKTKVNVKS 480
VKRNTDVPES QQNFHRPVKV RKKQIDKEPK IQSCNSGVKS VKNQAHSVLK KTLQDQTLVQ 540
IFKPLTHSLS DKSHAHPGCL KEPHHPAQTG HVSHSSQKQC HKPQQQAPAM KTNSHVKEEL 600
EHPGVEHFKE EDKLKLKKPE KNLQPRQRRS SKSFSLDEPP LFIPDNIATI RREGSDHSSS 660
FESKYMWTPS KQCGFCKKPH GNRFMVGCGR CDDWFHGDCV GLSLSQAQQM GEEDKEYVCV 720
KCCAEEDKKT EILDPDTLEN QATVEFHSGD KTMECEKLGL SKHTTNDRTK YIDDTVKHKV 780
KILKRESGEG RNSSDCRDNE IKKWQLAPLR KMGQPVLPRR SS 822 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00628; PHD 
SMART
 SM00249; PHD 
PROSITE
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS