UniProt Accession

 YNG2_YEAST; P38806; D3DL42 

Genbank Protein ID

 U00060; BK006934 

Genbank Nucleotide ID

 AAB68930.1; DAA06786.1 

Protein Name

 Chromatin modification-related protein YNG2 

Protein Synonyms/Alias

 ESA1-associated factor 4; ING1 homolog 2 

Gene Name

 YNG2 

Gene Synonyms/Alias

 EAF4; NBN1; YHR090C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
145	VVSNSSVKKRRAASS	acetylation	[1]
146	VSNSSVKKRRAASSS	acetylation	[1]
170	KKTSRTSKLQNEIDV	acetylation	[1, 2]
208	FKNSRNGKGQNGSPE	acetylation	[1]

Reference

 [1] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis. 

Sequence Annotation

 ZN_FING 222 271 PHD-type.
 BINDING 224 224 Histone H3K4me3 (By similarity).
 BINDING 235 235 Histone H3K4me3 (By similarity).
 BINDING 239 239 Histone H3K4me3 (By similarity).
 BINDING 247 247 Histone H3K4me3 (By similarity).
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 185 185 Phosphothreonine.
 MOD_RES 188 188 Phosphoserine.  

Keyword

 Cell cycle; Chromatin regulator; Coiled coil; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; Meiosis; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IDA:SGD.
 GO:0035064; F:methylated histone residue binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006281; P:DNA repair; IDA:SGD.
 GO:0016573; P:histone acetylation; IDA:SGD.
 GO:0007126; P:meiosis; IEA:UniProtKB-KW. 

Interpro

 IPR024610; ING_N.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF12998; ING
 PF00628; PHD 

SMART

 SM00249; PHD 

PROSITE

 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 

PRINTS