UniProt Accession

 PTPM1_MOUSE; Q66GT5; Q9CSJ8; Q9D622 

Genbank Protein ID

 AK012674; AK014691; BC026750; BK005540 

Genbank Nucleotide ID

 BAB28400.1; BAB29504.1; AAH26750.1; DAA05585.1 

Protein Name

 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 

Protein Synonyms/Alias

 PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1 

Gene Name

 Ptpmt1 

Gene Synonyms/Alias

 Plip 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
85	RFLCNTSKEWKKAGV	acetylation	[1]
184	EVLKEFHKEITARAA	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). 

Sequence Annotation

 DOMAIN 109 177 Tyrosine-protein phosphatase.
 ACT_SITE 132 132 Phosphocysteine intermediate (By  

Keyword

 3D-structure; Complete proteome; Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Phospholipid biosynthesis; Phospholipid metabolism; Protein phosphatase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
 GO:0008962; F:phosphatidylglycerophosphatase activity; IMP:UniProtKB.
 GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:MGI.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
 GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
 GO:0046855; P:inositol phosphate dephosphorylation; IBA:RefGenome.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
 GO:0046488; P:phosphatidylinositol metabolic process; IC:MGI. 

Interpro

 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR024950; DUSP.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 

Pfam

 PF00782; DSPc 

SMART

  

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 

PRINTS