UniProt Accession

 GOSR1_RAT; Q62931; A0JN01 

Genbank Protein ID

 U49099; BC126068 

Genbank Nucleotide ID

 AAC52597.1; AAI26069.1 

Protein Name

 Golgi SNAP receptor complex member 1 

Protein Synonyms/Alias

 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28 

Gene Name

 Gosr1 

Gene Synonyms/Alias

 Gs28 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
124	DYTHEFHKTKANFMA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Direct protein sequencing; ER-Golgi transport; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 250 AA 

Protein Sequence

Gene Ontology

 GO:0005801; C:cis-Golgi network; IDA:RGD.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IDA:MGI.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IDA:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Compara. 

Interpro

 IPR023601; Golgi_SNAP_su1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS