UniProt Accession

 WECA_ECOLI; P0AC78; P24235; P76751; Q2M892; Q9F8C8 

Genbank Protein ID

 S75640; M76129; AF248031; M87049; U00096; AP009048 

Genbank Nucleotide ID

 AAB20842.1; AAA24526.1; AAG26342.1; AAA67584.1; AAC76789.1; BAE77514.1 

Protein Name

 Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase 

Protein Synonyms/Alias

 UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase 

Gene Name

 wecA 

Gene Synonyms/Alias

 rfe; b3784; JW3758 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
36	KKVGLVDKPNFRKRH	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis and an acceptor for the addition of subsequent sugars to complete the biosynthesis of O-antigen. The apparent affinity of WecA for the polyisoprenyl phosphate substrates increases with the polyisoprenyl chain length. WecA is unable to utilize dolichyl phosphate (Dol-P). 

Sequence Annotation

  

Keyword

 Cell inner membrane; Cell membrane; Complete proteome; Glycosyltransferase; Lipopolysaccharide biosynthesis; Magnesium; Manganese; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0009276; C:Gram-negative-bacterium-type cell wall; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IMP:UniProtKB.
 GO:0008144; F:drug binding; IDA:EcoliWiki.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0030145; F:manganese ion binding; IDA:UniProtKB.
 GO:0008963; F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity; IDA:EcoliWiki.
 GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.
 GO:0036380; F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity; IEA:EC.
 GO:0044038; P:cell wall macromolecule biosynthetic process; IDA:UniProtKB.
 GO:0071555; P:cell wall organization; IDA:UniProtKB.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IDA:UniProtKB.
 GO:0009243; P:O antigen biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR012750; ECA_WecA-rel.
 IPR000715; Glycosyl_transferase_4. 

Pfam

 PF00953; Glycos_transf_4 

SMART

  

PROSITE

  

PRINTS