UniProt Accession

 KAP0_MOUSE; Q9DBC7; Q3UKU7; Q9JHR5; Q9JHR6 

Genbank Protein ID

 AK005039; AK027916; AK051068; AK145797; AK145860; AK147188; AK150427; AK151124; AK153227; BC003461; BC005697; AJ278427; AJ278429 

Genbank Nucleotide ID

 BAB23766.1; BAC25664.1; BAC34516.1; BAE26655.1; BAE26704.1; BAE27748.1; BAE29550.1; BAE30132.1; BAE31820.1; AAH03461.1; AAH05697.1; CAB94778.1; CAB94718.1 

Protein Name

 cAMP-dependent protein kinase type I-alpha regulatory subunit 

Protein Synonyms/Alias

 cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 

Gene Name

 Prkar1a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
222	VKAKTNVKLWGIDRD	ubiquitination	[1]
252	MYEEFLSKVSILESL	ubiquitination	[1]
261	SILESLDKWERLTVA	ubiquitination	[1]
367	GPCSDILKRNIQQYN	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (By similarity). 

Sequence Annotation

 NP_BIND 137 254 cAMP 1.
 NP_BIND 255 381 cAMP 2.
 REGION 1 136 Dimerization and phosphorylation.
 MOTIF 96 100 Pseudophosphorylation motif.
 BINDING 202 202 cAMP 1.
 BINDING 211 211 cAMP 1.
 BINDING 326 326 cAMP 2.
 BINDING 335 335 cAMP 2.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylalanine (Probable).
 MOD_RES 77 77 Phosphoserine.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 101 101 Phosphoserine.
 DISULFID 18 18 Interchain (with C-39) (By similarity).
 DISULFID 39 39 Interchain (with C-18) (By similarity).  

Keyword

 Acetylation; cAMP; cAMP-binding; Cell membrane; Complete proteome; Disulfide bond; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:Compara.
 GO:0005737; C:cytoplasm; TAS:MGI.
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IDA:MGI.
 GO:0060038; P:cardiac muscle cell proliferation; IMP:MGI.
 GO:0007143; P:female meiosis; IEA:Compara.
 GO:0001707; P:mesoderm formation; IMP:MGI.
 GO:0045835; P:negative regulation of meiosis; IEA:Compara.
 GO:0006469; P:negative regulation of protein kinase activity; IMP:MGI.
 GO:0009887; P:organ morphogenesis; TAS:MGI.
 GO:0006468; P:protein phosphorylation; TAS:MGI.
 GO:0045214; P:sarcomere organization; IMP:MGI.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 

Pfam

 PF00027; cNMP_binding
 PF02197; RIIa 

SMART

 SM00100; cNMP
 SM00394; RIIa 

PROSITE

 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 

PRINTS

 PR00103; CAMPKINASE.