| Tag | Content |
|---|
| CPLM ID | CPLM-011352 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acetoacetate metabolism regulatory protein AtoC |
Protein Synonyms/Alias | Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor |
Gene Name | atoC |
Gene Synonyms/Alias | az; b2220; JW2214 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 333 | LANHFLQKFSSENQR | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis. |
Sequence Annotation | DOMAIN 6 120 Response regulatory.
DOMAIN 145 374 Sigma-54 factor interaction.
NP_BIND 236 245 ATP (Potential).
DNA_BIND 433 452 H-T-H motif (By similarity).
MOD_RES 55 55 4-aspartylphosphate (By similarity). |
Keyword | ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Two-component regulatory system. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MTAINRILIV DDEDNVRRML STAFALQGFE THCANNGRTA LHLFADIHPD VVLMDIRMPE 60
MDGIKALKEM RSHETRTPVI LMTAYAEVET AVEALRCGAF DYVIKPFDLD ELNLIVQRAL 120
QLQSMKKEIR HLHQALSTSW QWGHILTNSP AMMDICKDTA KIALSQASVL ISGESGTGKE 180
LIARAIHYNS RRAKGPFIKV NCAALPESLL ESELFGHEKG AFTGAQTLRQ GLFERANEGT 240
LLLDEIGEMP LVLQAKLLRI LQEREFERIG GHQTIKVDIR IIAATNRDLQ AMVKEGTFRE 300
DLFYRLNVIH LILPPLRDRR EDISLLANHF LQKFSSENQR DIIDIDPMAM SLLTAWSWPG 360
NIRELSNVIE RAVVMNSGPI IFSEDLPPQI RQPVCNAGEV KTAPVGERNL KEEIKRVEKR 420
IIMEVLEQQE GNRTRTALML GISRRALMYK LQEYGIDPAD V 461 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. GO:0035556; P:intracellular signal transduction; IEA:GOC. GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:EcoCyc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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