UniProt Accession

 RSMB_HUMAN; P14678; Q15490; Q6IB35; Q9UIS5 

Genbank Protein ID

 X17567; X17568; X15893; AF134825; AF134822; AF134823; AF134824; AL049650; CH471133; CR456969; AL049650; M34081; M34082; X52979; X52979 

Genbank Nucleotide ID

 CAB57867.1; CAB57868.1; CAA33902.1; AAD54488.1; AAD54488.1; AAD54488.1; AAD54488.1; CAB46715.1; EAX10596.1; CAG33250.1; CAB46714.1; AAA36578.1; AAA36579.1; CAA37170.1; CAA37171.1 

Protein Name

 Small nuclear ribonucleoprotein-associated proteins B and B' 

Protein Synonyms/Alias

 snRNP-B; Sm protein B/B'; Sm-B/B'; SmB/B' 

Gene Name

 SNRPB 

Gene Synonyms/Alias

 COD; SNRPB1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MTVGKSSKMLQH	ubiquitination	[1]
8	MTVGKSSKMLQHIDY	acetylation	[2]
8	MTVGKSSKMLQHIDY	ubiquitination	[1, 3]
32	RIFIGTFKAFDKHMN	ubiquitination	[1, 3]
88	TVEGPPPKDTGIARV	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner (By similarity). 

Sequence Annotation

 REPEAT 175 181
 REPEAT 191 196
 REPEAT 216 221
 REPEAT 222 228
 REPEAT 230 236
 REGION 175 236 Repeat-rich region.
 MOD_RES 108 108 Omega-N-methylated arginine.
 MOD_RES 112 112 Dimethylated arginine; in A2780 ovarian
 MOD_RES 112 112 Omega-N-methylated arginine.
 MOD_RES 147 147 Omega-N-methylarginine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Polymorphism; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 240 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0071204; C:histone pre-mRNA 3'end processing complex; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005689; C:U12-type spliceosomal complex; IDA:UniProtKB.
 GO:0005683; C:U7 snRNP; IDA:UniProtKB.
 GO:0071208; F:histone pre-mRNA DCP binding; IEA:Compara.
 GO:0008334; P:histone mRNA metabolic process; TAS:Reactome.
 GO:0031124; P:mRNA 3'-end processing; TAS:Reactome.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:Reactome.
 GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome. 

Interpro

 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc.
 IPR017131; snRNP-assoc_SmB/SmN. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS