UniProt Accession

 NUSAP_HUMAN; Q9BXS6; B4DDF1; E7ERR5; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9GZM9; Q9NZ85; Q9UI70 

Genbank Protein ID

 AF290612; AF305711; AF090915; AK023483; AK293168; AK222819; AL833611; AC087721; CH471125; CH471125; BC001308; BC010838; BC012887; BC024772; AF217513 

Genbank Nucleotide ID

 AAK28023.1; AAG25874.1; AAF24034.1; BAB14586.1; BAG56712.1; BAD96539.1; EAW92483.1; EAW92486.1; AAH01308.1; AAH10838.2; AAH12887.2; AAH24772.1; AAF67624.1 

Protein Name

 Nucleolar and spindle-associated protein 1 

Protein Synonyms/Alias

 NuSAP 

Gene Name

 NUSAP1 

Gene Synonyms/Alias

 ANKT; BM-037; PRO0310 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
327	VLGTHKLKTITGNSA	ubiquitination	[1]
411	KQPHLQTKEEQRKKR	acetylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. 

Sequence Annotation

 REGION 237 382 Interaction with microtubules (By
 MOTIF 384 390 KEN box.
 MOD_RES 124 124 Phosphoserine; by ATM.
 MOD_RES 135 135 Phosphoserine.
 MOD_RES 182 182 Phosphothreonine.
 MOD_RES 240 240 Phosphoserine.
 MOD_RES 244 244 Phosphothreonine.
 MOD_RES 247 247 Phosphoserine.
 MOD_RES 276 276 Phosphoserine.
 MOD_RES 311 311 Phosphoserine.
 MOD_RES 314 314 Phosphothreonine.
 MOD_RES 338 338 Phosphothreonine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 411 411 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; DNA-binding; Microtubule; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 441 AA 

Protein Sequence

Gene Ontology

 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0040001; P:establishment of mitotic spindle localization; IDA:MGI.
 GO:0007076; P:mitotic chromosome condensation; IDA:MGI.
 GO:0000281; P:mitotic cytokinesis; IDA:MGI.
 GO:0045840; P:positive regulation of mitosis; IDA:MGI. 

Interpro

 IPR026756; NuSAP. 

Pfam

  

SMART

  

PROSITE

  

PRINTS