| Tag | Content |
|---|
| CPLM ID | CPLM-013426 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kinesin-like protein KIF26A |
Protein Synonyms/Alias | |
Gene Name | Kif26a |
Gene Synonyms/Alias | Kiaa1236 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1796 | RLQEVQAKRDHLCEE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity. |
Sequence Annotation | DOMAIN 361 654 Kinesin-motor.
NP_BIND 462 469 ATP (Potential). |
Keyword | ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1881 AA |
Protein Sequence | MVGRGASLCA VQPAVAECGP ARETPPLEVS PRKRLPAGLD QDPCSSRPAP EGAGASAEQS 60
HSAGGGGWCR HCHTKLVELK RQAWKLVSGP GTPLRDPCLS TLLLDKLPAS GVQPACRPDT 120
ESRCDVCTTH LHQLTREALR LLQTPASHED PNASRGGLAA PSSRDPPGPV GLMGRQPPVG 180
PDRRKATAWP PGPSVQVSVA PAGLGGALST VTIQAQQCLE GVWSLSRVNS FLPPTCLAEA 240
AVAAVAVADT VRDCAPAAGP ERMSKAWGRG AACTTALVTP APGTSAGGST GPSAAASFFI 300
RAAQKLSLAS KRKKHHPPPA PSTRGTSTYP TDFSGSLQLW PPPVPPCLLR AASKAKENPS 360
SFGKVKVMLR IWPAQGVQRS AESTSFLKVD SRKKQVTLYD PAAGPPGCAG LRHAPTAPVP 420
KMFAFDAIFP QDSEQAEVCS GTVADVLQSV VSGADGCIFS FGHMSLGKSY TMIGKDSSPQ 480
SLGIVPCAIS WLFRLIDERK ERLGTRFSIR VSAVEVCGHD QSLRDLLAEV ASGSLQDTQS 540
PGVYLREDPV CGTQLQNQNE LRAPTAEKAA FYLDAALAAR STSRAGCGEE ARRSSHMLFT 600
LHVYQYRVEK CGQGGMSGGR SRLHLIDLGS CDAAVGRGGE ASGGPLCLSL SALGSVILAL 660
VNGAKHVPYR DHRLTMLLRE SLATTNCRTT MIAHISDSPA HHAETLSTVQ LAARIHRLRR 720
KKGKHASSSS GGESSCEEGR ARRPPHLRPF HPRAVVLDPD RSAPGLSGDP DYSSSSEQSC 780
DTVIYVGPGG MALSDRELTD NEGPPDFVPI IPALSRRRPS EGPRDADHFR CSTFAELQER 840
LECIDGSEAF PGPQGGSDGA QASPARGGRK PSLPEATPSR KAVAPTVVTS CPRGSPGHDT 900
HRSASDPSKT GTQSEQRVDG SRPEPPASDK TSGGGGRRPL PSPAPPPPRQ PEAQGIPKEP 960
GGEGTDSVLR TPPVGMSGQA ALPPLLSDSA YLSPSARGRH LERGLLTTTV TLQQPVELNG 1020
EDELVFTVVE ELPLGGLAGA TRPSSLASMS SDCSLQALAS GSRPVSIISS INDEFDAYTS 1080
QMSEGPGDPG EFPEGTAWAG GSPASSIGSW LSDVGVCLSE SRGPTPQPPF SPNSAAGPGP 1140
PEFPTPGSSL EESKVRSSEC GRPDNPGSAR SLHPGEAVAT TQTQPGREPW ARSPHEVASA 1200
QTIHSSLPRK PRTTSTASRA RPSRGPYSPG GLFEDPWLLR AEDCDTRQIA STGRAPSPTP 1260
GSPRLPETQM MLACAQRVVD GCEVASRMSR RPEAVARIPP LRRGATTLGV TTPAASCGDA 1320
PAEAVVHSGS LKTTSGSKKS VSPKGAFFPR PSGAGPPAPP VRKSSLEQST ALTPTQALGL 1380
TRAGAPSAFR GEEEARPSGR SDSSVPKATS SLKARAGKMD VPYRPSGHMS LERCEGLAHG 1440
SSKVRDVVGR PPRAVPRLGV PSASPPLGPA PACRNSPAKG VGATKPPAGG AKGRNLGPST 1500
SRALGAPVKP LGPVAGKTAG GAVPGPRAAP RAVPGIGAKA GRGTIMGTKQ AFRAAHSRVH 1560
ELAASGSPSR GGLSWGSTDS DSGNDSGVNL AEERQPSSPA LPSPYSKVTA PRRPQRYSSG 1620
HGSDNSSVLS GELPPAMGRT ALFYHSGGSS GYESMIRDSE ATGSASSAPD SMSESGTASL 1680
GARSRSLKSP KKRATGLQRR RLIPAPLPDA AALGRKPSLP GQWVDLPPPL AGSLKEPFEI 1740
KVYEIDDVER LQRHRLPLRE NEAKPSQDAE KGPVCISSKL RLAERRQQRL QEVQAKRDHL 1800
CEELAETQGR LMVEPGRWLE QFEVDPELEP ESAEYLVALE QATAALEQCV NLCKAHVMMV 1860
TCFDIGVAAT TAVPGPQEVD V 1881 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005875; C:microtubule associated complex; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008017; F:microtubule binding; IDA:UniProtKB. GO:0048484; P:enteric nervous system development; IMP:UniProtKB. GO:0009968; P:negative regulation of signal transduction; IMP:UniProtKB. GO:0001560; P:regulation of cell growth by extracellular stimulus; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |