UniProt Accession

 G6PD_YEAST; P11412; D6W0V2; E9P908 

Genbank Protein ID

 M34709; X57336; Z69381; Z71517; AY692998; BK006947 

Genbank Nucleotide ID

 AAA34619.1; CAA40611.1; CAA93357.1; CAA96146.1; AAT93017.1; DAA10318.1 

Protein Name

 Glucose-6-phosphate 1-dehydrogenase 

Protein Synonyms/Alias

 G6PD 

Gene Name

 ZWF1 

Gene Synonyms/Alias

 MET19; YNL241C; N1110 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
110	ELRTQIEKFEKSANV	acetylation	[1]
113	TQIEKFEKSANVDVP	acetylation	[1]
157	ITRVIVEKPFGHDLA	acetylation	[1]
157	ITRVIVEKPFGHDLA	ubiquitination	[2]
171	ASARELQKNLGPLFK	acetylation	[1]
191	RIDHYLGKELVKNLL	acetylation	[1]
349	GKALNESKVEIRLQY	ubiquitination	[2]
365	AVASGVFKDIPNNEL	acetylation	[1]
389	VYLKFNAKTPGLSNA	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). 

Sequence Annotation

 NP_BIND 18 25 NADP (By similarity).
 REGION 187 191 Substrate binding (By similarity).
 ACT_SITE 249 249 Proton acceptor (By similarity).
 BINDING 52 52 NADP (By similarity).
 BINDING 157 157 NADP; via carbonyl oxygen (By
 BINDING 157 157 Substrate (By similarity).
 BINDING 225 225 Substrate (By similarity).
 BINDING 244 244 Substrate (By similarity).
 BINDING 343 343 Substrate (By similarity).
 BINDING 377 377 Substrate (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 145 145 Phosphotyrosine.  

Keyword

 Acetylation; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glucose metabolism; NADP; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 505 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IMP:SGD.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0009051; P:pentose-phosphate shunt, oxidative branch; IMP:SGD.
 GO:0042542; P:response to hydrogen peroxide; IMP:SGD. 

Interpro

 IPR001282; G6P_DH.
 IPR019796; G6P_DH_AS.
 IPR022675; G6P_DH_C.
 IPR022674; G6P_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02781; G6PD_C
 PF00479; G6PD_N 

SMART

  

PROSITE

 PS00069; G6P_DEHYDROGENASE 

PRINTS

 PR00079; G6PDHDRGNASE.