CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000815
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/potassium/calcium exchanger 2 
Protein Synonyms/Alias
 Na(+)/K(+)/Ca(2+)-exchange protein 2; Retinal cone Na-Ca+K exchanger 
Gene Name
 Slc24a2 
Gene Synonyms/Alias
 Nckx2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
302INRNKVVKVTVSEAQubiquitination[1]
311TVSEAQAKASTAGDKubiquitination[1]
326EEPTLPNKPRLQRGGubiquitination[1]
369LGSYGKLKYYDTMTEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). 
Sequence Annotation
 REPEAT 175 215 Alpha-1.
 REPEAT 550 581 Alpha-2.
 CARBOHYD 112 112 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Antiport; Calcium; Calcium transport; Complete proteome; Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Repeat; Sensory transduction; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 670 AA 
Protein Sequence
MDLHQSATVR LLQEWCSHES PSGCRRHYNT RKKLKLIRVI GLVMGLVAVS TVPFSISAFT 60
ETYSQNNRGE ASDVTGPRAA PGHRQRTLLD LNDKIRDYTP QPPASQEDRS ENGTDHAQGD 120
YPKDVFSLEE RRKGAIILHV IGMIYMFIAL AIVCDEFFVP SLTVITEKLG ISDDVAGATF 180
MAAGGSAPEL FTSLIGVFIA HSNVGIGTIV GSAVFNILFV IGMCALFSRE ILNLTWWPLF 240
RDVSFYIVDL IMLIIFFLDN VIMWWESLLL LTAYFAYVVF MKFNVQVERW VKQMINRNKV 300
VKVTVSEAQA KASTAGDKEE PTLPNKPRLQ RGGSSASLHN SLMRNSIFQL MIHTLDPLAE 360
ELGSYGKLKY YDTMTEEGRF REKASILHKI AKKKCQVDEN ERQNGAANHV DYAAEKIELP 420
NSTSTEVEMT PSSEASEPVQ NGNLSHSIEA ADAPQATETA EEDDDQPLSL SWPSNTRKQI 480
TFLIVLPIVF PLWITLPDVR KPASKKFFPI TFFGSITWIA VFSYLMVWWA HQVGETIGIS 540
EEIMGLTILA AGTSIPDLIT SVIVARKGLG DMAVSSSVGS NIFDITVGLP LPWLLYTIIH 600
RFKPVTVSSN GLFCAIVLLF IMLIFVILSI ALCKWRMNKI LGFIMFGLYF AFLVVSVLLE 660
DKVLECPVSI 670 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031226; C:intrinsic to plasma membrane; IMP:RGD.
 GO:0046870; F:cadmium ion binding; IMP:RGD.
 GO:0005262; F:calcium channel activity; IEA:Compara.
 GO:0005509; F:calcium ion binding; IMP:RGD.
 GO:0008273; F:calcium, potassium:sodium antiporter activity; IDA:RGD.
 GO:0030145; F:manganese ion binding; IMP:RGD.
 GO:0016151; F:nickel cation binding; IMP:RGD.
 GO:0030955; F:potassium ion binding; IMP:RGD.
 GO:0046983; F:protein dimerization activity; IMP:RGD.
 GO:0031402; F:sodium ion binding; IMP:RGD.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0007612; P:learning; IEA:Compara.
 GO:0060292; P:long term synaptic depression; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR004481; K/Na/Ca-exchanger.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF01699; Na_Ca_ex 
SMART
  
PROSITE
  
PRINTS