CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041878
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 26 member 6 
Protein Synonyms/Alias
 Solute carrier family 26, member 6, isoform CRA_i 
Gene Name
 SLC26A6 
Gene Synonyms/Alias
 hCG_1999608 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
522SNNVEDCKMMVSSGDubiquitination[1, 2]
530MMVSSGDKMEDATANubiquitination[1, 2, 3]
543ANGQEDSKAPDGSTLubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 651 AA 
Protein Sequence
MGLADASGPR DTQALLSATQ AMDLRRRDYH MERPLLNQEH LEELGRWGSA PRTHQWRTWL 60
QCSRARAYAL LLQHLPVLVW LPRYPVRDWL LGDLLSGLSV AIMQLPQGLA YALLAGLPPV 120
FGLYSSFYPV FIYFLFGTSR HISVVLEVCW KLPQSKVGTV VTAAVAGVVL VVVKLLNDKL 180
QQQLPMPIPG ELLTLIGATG ISYGMGLKHR FEVDVVGNIP AGLVPPVAPN TQLFSKLVGS 240
AFTIAVVGFA IAISLGKIFA LRHGYRVDSN QELVALGLSN LIGGIFQCFP VSCSMSRSLV 300
QESTGGNSQV AGAISSLFIL LIIVKLGELF HDLPKAVLAA IIIVNLKGML RQLSDMRSLW 360
KANRADLLIW LVTFTATILL NLDLGLVVAV IFSLLLVVVR TQMPHYSVLG QVPDTDIYRD 420
VAEYSEAKEV RGVKVFRSSA TVYFANAEFY SDALKQRCGV DVDFLISQKK KLLKKQEQLK 480
LKQLQKEEKL RKQAASPKGA SVSINVNTSL EDMRSNNVED CKMMVSSGDK MEDATANGQE 540
DSKAPDGSTL KALGLPQPDF HSLILDLGAL SFVDTVCLKS LKNIFHDFRE IEVEVYMAAC 600
HSPVVSQLEA GHFFDASITK KHLFASVHDA VTFALQHPRP VPDSPVSVTR L 651 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
 GO:0008272; P:sulfate transport; IEA:InterPro. 
Interpro
 IPR018045; S04_transporter_CS.
 IPR002645; STAS_dom.
 IPR011547; Sulph_transpt. 
Pfam
 PF01740; STAS
 PF00916; Sulfate_transp 
SMART
  
PROSITE
 PS01130; SLC26A
 PS50801; STAS 
PRINTS