CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012353
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plastin-1 
Protein Synonyms/Alias
 Intestine-specific plastin; I-plastin 
Gene Name
 PLS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
333INETNDLKRAGLMLQubiquitination[1, 2]
623VFACLMGKGLNRIK*ubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Actin-bundling protein in the absence of calcium. 
Sequence Annotation
 DOMAIN 11 46 EF-hand 1.
 DOMAIN 51 86 EF-hand 2.
 DOMAIN 108 380 Actin-binding 1.
 DOMAIN 122 238 CH 1.
 DOMAIN 266 376 CH 2.
 DOMAIN 381 625 Actin-binding 2.
 DOMAIN 395 504 CH 3.
 DOMAIN 516 625 CH 4.  
Keyword
 Actin-binding; Calcium; Complete proteome; Cytoplasm; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 629 AA 
Protein Sequence
MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY KVREIVEKIL 60
SVADSNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE GITAIGGTST ISSEGTQHSY 120
SEEEKVAFVN WINKALENDP DCKHLIPMNP NDDSLFKSLA DGILLCKMIN LSEPDTIDER 180
AINKKKLTPF TISENLNLAL NSASAIGCTV VNIGASDLKE GKPHLVLGLL WQIIKVGLFA 240
DIEISRNEAL IALLNEGEEL EELMKLSPEE LLLRWVNYHL TNAGWHTISN FSQDIKDSRA 300
YFHLLNQIAP KGGEDGPAIA IDLSGINETN DLKRAGLMLQ EADKLGCKQF VTPADVVSGN 360
PKLNLAFVAN LFNTYPCLHK PNNNDIDMNL LEGESKEERT FRNWMNSLGV NPYINHLYSD 420
LADALVIFQL YEMIRVPVNW SHVNKPPYPA LGGNMKKIEN CNYAVELGKN KAKFSLVGIA 480
GQDLNEGNST LTLALVWQLM RRYTLNVLSD LGEGEKVNDE IIIKWVNQTL KSANKKTSIS 540
SFKDKSISTS LPVLDLIDAI APNAVRQEMI RRENLSDEDK LNNAKYAISV ARKIGARIYA 600
LPDDLVEVKP KMVMTVFACL MGKGLNRIK 629 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0051015; F:actin filament binding; TAS:ProtInc.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF00307; CH
 PF13405; EF_hand_4
 PF00036; efhand 
SMART
 SM00033; CH
 SM00054; EFh 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS