CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003868
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin 
Protein Synonyms/Alias
  
Gene Name
 act1 
Gene Synonyms/Alias
 cps8; pi012; SPBC32H8.12c 
Created Date
 July 27, 2013 
Organism
 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 
NCBI Taxa ID
 284812 
Lysine Modification
Position
Peptide
Type
References
68KRGILTLKYPIEHGIsumoylation[1]
284ATYNSIMKCDVDIRKsumoylation[1]
Reference
 [1] SUMOylation of nuclear actin.
 Hofmann WA, Arduini A, Nicol SM, Camacho CJ, Lessard JL, Fuller-Pace FV, de Lanerolle P.
 J Cell Biol. 2009 Jul 27;186(2):193-200. [PMID: 19635839] 
Functional Description
 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 
Sequence Annotation
 MOD_RES 202 202 Phosphothreonine.
 MOD_RES 324 324 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH HGIMVGMGQK DSYVGDEAQS 60
KRGILTLKYP IEHGIVNNWD DMEKIWHHTF YNELRVAPEE HPCLLTEAPL NPKSNREKMT 120
QIIFETFNAP AFYVAIQAVL SLYASGRTTG IVLDSGDGVT HTVPIYEGYA LPHAIMRLDL 180
AGRDLTDYLM KILMERGYTF STTAEREIVR DIKEKLCYVA LDFEQELQTA AQSSSLEKSY 240
ELPDGQVITI GNERFRAPEA LFQPSALGLE NAGIHEATYN SIMKCDVDIR KDLYGNVVMS 300
GGTTMYPGIA DRMQKEIQAL APSSMKVKIV APPERKYSVW IGGSILASLS TFQQMWISKQ 360
EYDESGPGIV YRKCF 375 
Gene Ontology
 GO:0030479; C:actin cortical patch; ISS:PomBase.
 GO:0005884; C:actin filament; TAS:PomBase.
 GO:0005826; C:actomyosin contractile ring; TAS:PomBase.
 GO:0051286; C:cell tip; IDA:PomBase.
 GO:0031011; C:Ino80 complex; IDA:PomBase.
 GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:PomBase.
 GO:0005628; C:prospore membrane; IDA:PomBase.
 GO:0000812; C:Swr1 complex; IDA:PomBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; IGI:PomBase.
 GO:0071963; P:establishment or maintenance of cell polarity regulating cell shape; IMP:PomBase.
 GO:0009272; P:fungal-type cell wall biogenesis; IMP:PomBase.
 GO:0016573; P:histone acetylation; IC:PomBase.
 GO:0030100; P:regulation of endocytosis; IMP:PomBase. 
Interpro
 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 
PRINTS
 PR00190; ACTIN.