CPLM-003707

Genbank Nucleotide ID

Protein Synonyms/Alias

Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2

Mus musculus (Mouse)

Position	Peptide	Type	References
29	TIENVKAKIQDKEGI	ubiquitination	[1]
33	VKAKIQDKEGIPPDQ	ubiquitination	[1]
48	QRLIFAGKQLEDGRT	ubiquitination	[1]
63	LSDYNIQKESTLHLV	ubiquitination	[1]
82	GGMQIFVKTLTGKTI	ubiquitination	[2]
695	FVKTLTGKTITLDVE	ubiquitination	[2]
708	VEPSVTTKKVKQEDR	ubiquitination	[2]

[1] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

DOMAIN 1 76 Ubiquitin-like 1.
DOMAIN 77 152 Ubiquitin-like 2.
DOMAIN 153 228 Ubiquitin-like 3.
DOMAIN 229 304 Ubiquitin-like 4.
DOMAIN 305 380 Ubiquitin-like 5.
DOMAIN 381 456 Ubiquitin-like 6.
DOMAIN 457 532 Ubiquitin-like 7.
DOMAIN 533 608 Ubiquitin-like 8.
DOMAIN 609 684 Ubiquitin-like 9.
BINDING 54 54 Activating enzyme.
BINDING 72 72 Activating enzyme.
MOD_RES 57 57 Phosphoserine.
CROSSLNK 6 6 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 11 11 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 27 27 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 29 29 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 33 33 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 48 48 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 63 63 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 76 76 Glycyl lysine isopeptide (Gly-Lys)

3D-structure; Complete proteome; Cytoplasm; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0010992; P:ubiquitin homeostasis; IGI:MGI.

IPR000626; Ubiquitin.
IPR019954; Ubiquitin_CS.
IPR019956; Ubiquitin_subgr.
IPR019955; Ubiquitin_supergroup.

PS00299; UBIQUITIN_1
PS50053; UBIQUITIN_2