UniProt Accession

 A4D1L5_HUMAN; A4D1L5 

Genbank Protein ID

 AB451490; CH236950; CH471070 

Genbank Nucleotide ID

 BAG70304.1; EAL24098.1; EAW83734.1 

Protein Name

 Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) 

Protein Synonyms/Alias

 Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast), isoform CRA_b; Ubiquitin-conjugating enzyme E2H isoform 1 

Gene Name

 UBE2H 

Gene Synonyms/Alias

 hCG_18056 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	VRVDLPDKYPFKSPS	ubiquitination	[1, 2]
64	LPDKYPFKSPSIGFM	ubiquitination	[2]
147	KIKEYIQKYATEEAL	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Ligase; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 183 AA 

Protein Sequence

Gene Ontology

 GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS